Trombini, Heisler, Caetano da Silva Corcini, Badke, and Schimith: Potential Therapeutic use of Anredera cordifolia in Chronic Non-Communicable Diseases: A Scoping Review*

Introduction

In Brazil's Unified Health System, integrative and complementary health practices (PICS) are crucial in achieving one of its foundational principles: Integrality. These practices represent treatments that draw on traditional knowledge and utilize therapeutic resources aimed at preventing a range of diseases, including hypertension and diabetes mellitus (DM). Thus, applying these practices can promote health beyond the physical realm, considering they encompass social, cultural, and emotional concerns within a multidisciplinary approach ¹^,².

Currently, approximately 29 PICS are available at no cost within Brazil's public healthcare system, with the utilization of medicinal plants being particularly notable. These plants, whether cultivated or wild, can be administered through various methods, such as orally or via infusion, and possess therapeutic effects. However, similar to any medication, they must be employed judiciously due to potential risks of adverse effects, contraindications, or interactions ².

Brazil boasts the highest level of biodiversity worldwide, accounting for 15-20 % of all known species. Plant life, a key component of this biodiversity, is the foundation for home remedies in traditional medicine. Furthermore, Brazil's rich cultural and ethnic diversity has fostered a wealth of knowledge about managing and utilizing medicinal plants, which has been endowed through successive generations ³^,⁴.

In 2019, chronic non-communicable diseases (NCDs) accounted for 75 % of morbidity and mortality among the Brazilian population ⁵; NCDs are chronic conditions generally attributable to multiple factors, characterized by a gradual onset and prolonged or indefinite duration ⁶. They arise from lifestyle-related factors such as unhealthy diets, physical inactivity, smoking, and alcohol consumption ⁷.

When used responsibly, medicinal plants can play a pivotal role as a complementary and integrative approach to treating NCDs. Various species offer therapeutic benefits and functional properties, in addition to being accessible and cost-effective ⁸. Among the native plants of Brazil, many are acknowledged for their therapeutic and nutritional value by both traditional and scientific medicine ⁹. For example, Anredera cordifolia (Ten.) Steenis is a species native to Brazil found in various regions but is not endemic ¹⁰. A. cordifolia is primarily recognized for its nutritional value; it is a plant with high nutrient content and biomass yield, classified as an unconventional food plant ¹¹.

Studies on A. cordifolia have highlighted its varied popular names in Brazil, including bertalhacoração, madeira vine, and folha gorda¹²^-¹⁴. In traditional medicine, the plant is valued for its therapeutic properties in treating skin diseases, DM, and hypertension ¹³. There is also documentation on its anti-inflammatory, antibacterial, anti-ulcer, and healing properties ¹⁵^-¹⁷. However, despite experimental studies confirming those effects, the understanding of its properties remains in the early stages ¹⁵^-¹⁷.

Hence, examining the existing evidence concerning its use and potentially identifying gaps in our knowledge is essential. Given the context described and the increasing interest in therapeutic practices involving medicinal plants, particularly the therapeutic potential of A. cordifolia, the significance of this study is evident. This study sought to survey both national and international scientific literature on the properties of A. cordifolia within the therapeutic management of NCDs.

Materials and Method

This study comprises a scoping review, a type of systematic literature review that adopts the PCC research approach, where P stands for population, C for concept, and the second C for context. This type of review is utilized to map the key concepts underpinning a research field and elucidate the definitions and conceptual limits of a topic (i.e., provide an overview or evidence map) ¹⁸.

The purposes of this method include serving as a precursor to a systematic review, identifying the types of evidence available in a specific field, analyzing knowledge gaps, elucidating the main concepts/definitions in the literature, examining research methodologies within a given topic or field, and identifying the principal characteristics or factors related to a concept ¹⁹.

A scoping review initiates with the development of a protocol, which acts as a blueprint and is crucial to minimize bias occurrence ¹⁸. For this study, a protocol was formulated and registered on the Open Science Framework platform. The review question posed was as follows: What are the properties of A. cordifolia in the therapeutic process of NCDs in laboratory studies involving humans, animals, and cell models?

The inclusion criteria were: a) studies involving human beings, animals, or cell models; b) studies investigating the therapeutic properties of the plant in NCDs; c) experiments executed in a laboratory setting; d) primary studies; e) studies regardless of the language, country of origin, or timeframe. The exclusion criteria consisted of incomplete or unavailable articles; duplicates were also excluded.

The search was conducted in July and August 2022 and updated in August 2023, using the Medline/PubMed, Scopus, and Web of Science databases, as well as the reference lists of the included studies after an exhaustive reading. The controlled descriptor searches were conducted in the Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) databases, while non-controlled descriptors were identified by reviewing the titles and abstracts of previously published studies. The search strategies applied to each data source are described in Table 1.

Table 1

Data Sources and search Strategies, Santa Maria, Rio Grande do Sul, Brazil, 2023

Database	Search strings
Medline via PubMed	((“anredera cordifolia”[Title/Abstract]) OR (“binahong”[Title/Abstract])) OR (“madeira vine”[Title/Abstract])
Scopus	“anredera cordifolia” OR “madeira vine” OR binahong
Web of Science	ALL = (anredera cordifolia OR madeira vine OR binahong)

[i]Source: Elaborated by the authors.

The selection of evidence was conducted in a double-independent manner, with a third reviewer available in case of any disagreements. The studies retrieved from the data sources were transferred to the Rayyan software; their titles and abstracts were reviewed, followed by a full reading of the selected articles and a critical assessment of the reference lists.

For data extraction, a script was devised containing relevant information to map the data, including author/year, country of study/ language, part of the plant and type of extract used, experimental model utilized, NCD or clinical marker researched, and the therapeutic properties of the plant in NCDs.

The data underwent coding and content analysis, as proposed in the literature (20). The results will be presented below, accompanied by descriptive summaries and in-depth discussions based on the existing literature.

Results

The search yielded 635 studies, of which 31 were selected for comprehensive review. Among them, eight were excluded due to duplication, and, upon detailed review, four more were excluded for failing to meet the selection criteria. This resulted in a total of 19 articles. Further evaluation of the reference lists of these studies led to the inclusion of an additional 11 studies, composing a final corpus of 27 articles (Figure 1).

Figure 1

Study's design Flowchart Based on the PRISMA Extension for Scoping Reviews (PRISMA-ScR), Santa Maria, Rio Grande do Sul, Brazil, 2023

Source: Elaborated by the authors.

All the studies were conducted in Asia, written predominantly in English, and conducted by the same researchers (Table 2).

Table 2 also indicates that 26 studies utilized ethanolic leaf extract, and one used leaf powder ²⁴, with only five studies specifying the concentration of the extract ²²^,²⁶^,³³^,³⁷^,³⁸. The most common dose used in the experiments was 100 mg/kg, as noted in 11 studies ²⁵^,²⁷^,³⁰^-³²^,³⁵^-³⁷^,³⁹^,⁴³^,⁴⁵.

Table 2

Characterization of the Studies, Santa Maria, Rio Grande do Sul, Brazil, 2023

Author and publication year	Country and language	Plant part, extract type, concentration, and/or dose used	NCD or clinical marker	Population model
Dwitiyanti et al. (2021) ²¹	Indonesia English	Leaves/ethanolic extract (50 mg/kg)	DM	Rats (in vivo)
Feriyani et al. (2021) ²²	Indonesia English	Leaves/ethanolic extract (100, 200 μg; concentration)	Cataract	Goat lenses (in vitro)
Sukandar et al. (2021) ²³	Japan English	Leaves/ethanolic extract (50 mg/kg)	HT	Rats (in vivo)
Hashimoto et al. (2022) ²⁴	Indonesia English	Leaves/leaf powder (1.12 g; powder	Triglycerides, glucose	Humans (in vivo)
Sukandar et al. 2011 ²⁵	Indonesia English	Leaves/ethanolic extract (50, 100, 150 mg/kg)	CKD	Rats (in vivo)
Sukandar et al. (2019) ²⁶	Indonesia English	Leaves/ethanolic extract (1 and 2 % concentrations; 50 mg/kg)	HT	Rats (in vivo)
Sukandar et al. (2013) ²⁷	Indonesia English	Leaves/ethanolic extract (100 mg/kg)	CKD	Rats (in vivo)
Dwitiyanti and Rorenza (2021) ²⁸	Indonesia English	Leaves/ethanolic extract (12.5, 25.50 mg/kg)	Cholesterol triglycerides	Rats (in vivo)
Bahtiar et al. (2021) ²⁹	Indonesia English	Leaves/ethanolic extract (75, 150, 300 mg/kg)	CKD	Rats (in vivo)
Garmana et al. (2016) ³⁰	Indonesia English	Leaves/ethanolic extract (100 mg/kg)	HT	Rats (in vivo)
Lestari et al. (2016) ³¹	Indonesia English	Leaves/ethanolic extract (50, 100, 200 mg/kg)	Cholesterol	Rats (in vivo)
Sukandar et al. (2016) ³²	Indonesia English	Leaves/ethanolic extract (100 mg/kg)	Cholesterol triglycerides	Rats (in vivo)
Sutrisno et al. (2018) ³³	Indonesia English	Leave/ethanolic extract (2 %; concentration)	DM	Rabbits (in vivo)
Wahjuni et al. (2019) ³⁴	Indonesia English	Leaves/ethanolic extract (20 mg/kg)	DM	Rats (in vivo)
Sukandar et al. (2016) ³⁵	Indonesia English	Leaves/ethanolic extract (100 mg/kg)	Obesity	Rats (in vivo)
Djamil et al. (2017) ³⁶	Indonesia English	Leaves/ethanolic extract (10, 50, 100 mg/kg)	DM	Mice (in vivo)
Garmana et al. (2018) ³⁷	Indonesia English	Leaves/ethanolic extract (12.86 % concentration; 50, 100, 200 mg/kg)	HT	Rats (in vivo)
Kintoko et al. (2016) ³⁸	Indonesia English	Leaves/ethanolic extract (10 and 30 % concentration; 150 mg/kg)	DM Obesity	Rats (in vivo)
Lestari et al. (2015) ³⁹	Indonesia English	Leaves/ethanolic extract (50, 100, 200 mg/kg)	Cholesterol triglycerides, obesity	Rats (in vivo)
Sukandar et al. (2016) ⁴⁰	Indonesia English	Leaves/ethanolic extract (0.9 mg/mL)	HT	Isolated rabbit aorta (in vitro); Frogs (in vivo)
Widyarini et al. (2015) ⁴¹	Indonesia English	Leaves/ethanolic extract (250 mg/kg)	Uric acid	Rats (in vivo)
Astuti et al. (2012) ⁴²	Indonesia English	Leaves and tubers (ethanolic extract)	DM	Rats (in vivo)
Wahjuni (2014) ⁴³	Indonesia English	Leaves/ethanolic extract (100 mg/kg)	Cholesterol	Rats (in vivo)
Sukandar et al. (2016) ⁴⁴	Indonesia English	Oleanolic acid and apigenin (extracted from the leaf extract); ethanolic extract/oleanolic acid (0.5 μg/mL); apigenin (0.05 μg/mL)	HT	Isolated rabbit aorta (in vitro); Frogs (in vivo)
Sukandar et al. (2011) ⁴⁵	Indonesia English	Leaves/ethanolic extract (50, 100, 200 mg/kg)	DM	Rats (in vivo)
Kusriani et al. (2023) ⁴⁶	Indonesia English	Leaves/ethanolic extract (15 g/mL)	DM	Rats (in vivo)
Sulfianti et al. (2023) ⁴⁷	Indonesia English	Leaves/ethanolic extract (250 mg/kg)	DM	Rats (in vivo)

[i]DM: Diabetes mellitus; HT: hypertension; CKD: chronic kidney disease. Source: research data.

[ii]Source: Elaborated by the authors.

Furthermore, DM and HT were the most frequently studied NCDs, with 9 studies on DM ²¹^,³³^,³⁴^,³⁶^,³⁸^,⁴²^,⁴⁵^-⁴⁷, and 6 studies on HT ²³^,²⁶^,³⁰^,³⁷^,⁴⁰^,⁴⁴. Three studies examined clinical markers of chronic kidney disease (CKD) ²⁵^,²⁷^,²⁹, 6 investigated serum cholesterol and triglyceride levels ²⁴^,²⁸^,³¹^,³²^,³⁹^,⁴³, 3 focused on obesity ³⁵^,³⁸^,³⁹, 1 on cataracts ²², and another one on serum uric acid levels ⁴¹.

As per the selection criteria for this review, all of the studies included had an experimental design with quantitative/statistical analysis: 1 with an in vitro population ²², 22 in vivo²¹^,²³^-³⁹^,⁴¹^-⁴³^,⁴⁵^-⁴⁷, and 2 studies that used both in vitro and in vivo models ⁴⁰^,⁴⁴. Of the in vitro studies, 1 was performed on goat lenses ²² and 2 on rabbit aortic rings ⁴⁰^,⁴⁴. The in vivo research comprised 21 studies conducted on rats ²¹^,²³^,²⁵^-³²^,³⁴^,³⁵^,³⁷^-³⁹^,⁴¹^-⁴³^,⁴⁵^-⁴⁷, 2 on frogs ⁴⁰^,⁴⁴, 1 on rabbits ³³, 1 on mice ³⁶, and 1 on humans ²⁴. Regarding the plant's therapeutic properties, the results of the studies included in this review are detailed in Table 3.

Table 3

Therapeutic Properties of the Plant A. cordifolia, Santa Maria, Rio Grande do Sul, Brazil, 2023

NCD/clinical marker	Therapeutic properties
DM	Hypoglycemic effect/reduced blood glucose levels ²¹^,²⁴^,³⁴^,³⁶^,⁴²^,⁴⁵^-⁴⁷
	Increased insulin secretion ⁴²
	Diabetic wound healing ³³^,³⁸
	Increased fibroblast cell proliferation ³³
	Improved glucose tolerance ²¹
	Increased water intake ³⁸
	Reduced fatty acids ²¹
	Increased essential amino acid concentrations ²¹
	Repairing effect on pancreatic beta cells ⁴⁵^,⁴⁷
	Reduced liver weight ²¹
HT	Decreased heart rate ³⁷^,⁴⁰
	Vasodilator effect ⁴⁰^,⁴⁴
	Reduced systolic blood pressure ²³^,³⁰
	Reduced diastolic blood pressure ²³^,³⁰
	Reduced blood pressure ²⁶^,⁴⁴
	Increased nitric oxide levels ³⁰
	Diuretic properties ³⁷
Lipid profile (cholesterol and triglycerides)	Reduced serum triglyceride levels ²⁴^,²⁸^,³¹^,³²^,³⁹
	Reduced LDL ³¹^,³²^,³⁹
	Increased HDL ³¹^,³⁹
	Reduced total cholesterol ²⁸^,³¹^,³²^,³⁹^,⁴³
CKD	Reduced serum creatinine level ²⁵^,²⁷^,²⁹
	Reduced serum urea concentration ²⁵^,²⁷
	Improved kidney structure ²⁷
	Increased antioxidant enzyme levels (catalase and superoxide dismutase) ²⁷^,²⁹
	Reduced hydronephrosis ²⁹
Obesity	Inhibition of body weight gain/fat layer reduction ³⁵^,³⁸^,³⁹
Uric acid	Anti-hyperuricemic effect, xanthine oxidase inhibitory activity ⁴¹
Cataract	Lowest degree of cataract ²²
Cataract	Reduced malondialdehyde ²²

[i]DM: Diabetes mellitus; HT: hypertension; CKD: chronic kidney disease; LDL: low-intensity lipoprotein; HDL: high-density lipoprotein.

[ii]Source: Elaborated by the authors.

Notably, the properties with the most scientific evidence pertain to a hypoglycemic effect or reduction in blood glucose levels ²¹^,²⁴^,³⁴^,³⁶^,⁴²^,⁴⁵^-⁴⁷. These are closely followed by those demonstrating reduced triglyceride levels ²⁴^,²⁸^,³¹^,³²^,³⁹ and decreased total cholesterol levels ²⁸^,³¹^,³²^,³⁹^,⁴³. Furthermore, the plant has shown beneficial effects on the healing of diabetic wounds ³³^,³⁸, in lowering systolic, diastolic blood pressure, and overall blood pressure ²³^,²⁶^,³⁰^,⁴⁴, in addressing obesity ³⁵^,³⁸^,³⁹, and in treating CKD. This treatment for CKD is evidenced by the reduction of creatinine levels ²⁵^,²⁷^,²⁹ and serum urea concentrations ²⁵^,²⁷, along with an increase in antioxidant enzyme levels ²⁷^,²⁹.

Discussion

Commonly, the first treatment option for chronic conditions includes drug therapy along with encouraging patients to change their lifestyles. An alternative, however, which remains underutilized, is the use of herbal medicine as a complement to conventional medication ⁴⁸. In Brazil, policies have been implemented to encourage the therapeutic use and production of herbal medicine under the supervision of the National Health Surveillance Agency ⁴⁹.

Diabetes mellitus is one of the most prevalent NCDs in the world. In 2021, 537 million individuals were diagnosed with DM, with Brazil accounting for 14.3 million of these cases ⁵⁰. It is characterized by persistent hyperglycemia ⁵¹, and various studies have demonstrated the hypoglycemic effect of various treatments ²¹^,²⁴^,³⁴^,³⁶^,⁴²^,⁴⁵^-⁴⁷. Hyperglycemia arises due to a deficiency in insulin production, action, or both ⁵¹. Specifically, the oral ingestion of the ethanolic extract of A. cordifolia has been documented to enhance insulin secretion ⁴². In the context of DM, pancreatic beta cells may be deficient, which are critical for insulin secretion and glucose tolerance ⁵¹^,⁵². It has been shown that oral treatment with this plant extract can repair these cells and improve glucose tolerance ²¹^,⁴⁵^,⁴⁷.

Moreover, an increase in the concentration of essential amino acids has been observed regarding DM ²¹. These amino acid chains play a pivotal role in protein synthesis within living organisms and are essential for muscle tissue strength, improved intestinal function, and blood sugar level regulation, among other functions ⁵³. They are crucial supplements for individuals with DM, as they can lower blood glucose levels, enhance insulin resistance, and alleviate oxidative stress ⁵⁴. Furthermore, they can reduce the likelihood of complications associated with DM, effectively diminishing the condition's damage ⁵⁵.

As for DM complications, the most prevalent and significant are microvascular alterations, particularly diabetic neuropathy. Diabetic peripheral neuropathy, the most common form, results from chronic hyperglycemia and cardiovascular risk factors, manifesting as a symmetrical, diffuse, distal, and progressive lesion of both autonomic and sensory-motor fibers. Affected individuals experience pain in the impacted area, negatively affecting their quality of life, functionality, and mood. It can lead to additional comorbidities such as anxiety, depression, insomnia, loss of functionality, and, notably, the diabetic foot ⁵².

With the global rise in DM prevalence, incidents of foot complications (e.g., diabetic foot) and infection and amputation rates have increased, constituting the most debilitating complications and leading to significant loss of functionality ⁵²^,⁵⁶. Two studies featured in this scoping review demonstrated the positive effects of A. cordifolia on healing diabetic wounds, with one utilizing an ointment combining the ethanolic extracts of the A. cordifolia and Centella asiatica plants at a 2 % concentration and the other employing a gel of the A. cordifolia leaf extract at concentrations of 10 and 30 % ³³^,³⁸. Its application has also been associated with an increase in fibroblast cell proliferation ³³, which is critical for the healing process as these cells form a layer differing in function and structure from the original tissue, thereby generating the scar and contributing to regeneration.

One study reported that ingesting the ethanolic extract of the plant led to a reduction in liver weight ²¹. The liver is crucial for carbohydrate metabolism, and the regulation of glucose homeostasis, and excessive fat deposition constitutes non-alcoholic fatty liver, a chronic liver disease linked with obesity, insulin resistance, and type 2 DM, affecting up to 30 % of the general population and significantly predisposing individuals to type 2 DM ⁵⁸.

Additionally, the oral administration of A. cordifolia extract has been shown to increase water intake and reduce fatty acid levels ²¹^,³⁸. Fatty acids, while essential for the normal functionality of beta cells, can lead to fat accumulation in muscles, liver, and pancreas when in excess ⁴⁵. Regarding water intake, hydration is critical in preventing and controlling DM, and low water consumption is associated with an increased risk of type 2 DM and cardiovascular, liver, and kidney problems ⁵⁹.

In terms of HT, the studies present promising outcomes. HT is characterized by a persistent rise in blood pressure, confirmed using the correct technique at least two separate times in the absence of antihypertensive medication. Controlling blood pressure to normal levels is vital for diminishing the risk of both micro and macrovascular complications ⁶⁰. In this context, the ethanolic extract from the leaves of A. cordifolia has proven effective in treating hypertension by reducing both systolic, diastolic blood ²³^,³⁰ and total blood pressure ²⁶^,⁴⁴.

Some factors directly influence blood pressure such as heart rate, which, when high, becomes a risk factor for the occurrence of adverse events and mortality in users with hypertension ⁶¹. Studies have shown that the plant's leaf extract reduces heart rate ³⁷^,⁴⁰, suggesting that research should be carried out on human beings, as the plant could be used to benefit people with hypertension.

Moreover, in experiments where the vasodilator effect was examined, the results were affirmatively in favor of using the extract ⁴⁰^,⁴⁴. The mechanisms of vasodilation and the application of drugs or phytomedicine that facilitate it are critically important in individuals with HT, as this process increases blood flow to the tissues and decreases blood pressure and central venous pressure, ultimately reducing cardiac workload ⁶².

Furthermore, the plant has demonstrated an ability to elevate nitric oxide levels and exhibited diuretic properties ³⁰^,³⁷. Nitric oxide plays a significant role in vasodilation, which leads to lower blood pressure and provides positive cardiac, renal, and vascular effects ⁶². Conversely, diuretics work to reduce intravascular volume through increased renal excretion of water and sodium. In cases of hypertension, the decline in intravascular volume results in decreased cardiac output and, consequently, a lowering of blood pressure ⁶³.

Continuing with NCDs, CKD is characterized by a long-term and gradual deterioration of kidney function, with the most common causes being diabetic nephropathy (a complication of DM) and hypertensive nephrosclerosis (a complication of HT) ⁶⁴. The diagnosis is based on various tests, including serum creatinine and urea levels. Creatinine is one of the biomarkers for CKD, whereas urea is extensively utilized in clinical settings to assess kidney function ⁶⁵. Research demonstrating the effects of A. cordifolia on rats with CKD has shown its efficacy in reducing serum creatinine levels and serum urea concentrations ²⁵^,²⁷^,²⁹. In addition, in the context of CKD, the use of the extract has led to improvements in kidney structure ²⁷, increased antioxidant enzymes catalase and superoxide dismutase levels ²⁷^,²⁹, and reduced hydronephrosis ²⁹. Antioxidant enzymes play a crucial role in the kidney's defensive mechanisms and in mitigating oxidative stress ⁶⁶, while hydronephrosis is a condition characterized by kidney enlargement due to the obstruction of urine flow into the bladder, caused by a blockage in the ureter ²⁹.

Another NCD for which evidence has been found is obesity. The application of the plant's ethanolic extract resulted in the inhibition of body weight increase and a diminution of the fat layer ³⁵^,³⁸^,³⁹. Obesity is a NCD of multifactorial origin, implying that excess weight is associated with the population's lifestyle, shaped by historical, biological, ecological, social, economic, cultural, and political factors ⁶⁷. It is also a risk factor for other NCDs, such as HT and DM ⁶⁸.

Turning to clinical markers influenced positively by A. cordifolia, the lipid profile (total cholesterol, low-intensity lipoprotein [LDL], high-density lipoprotein [HDL], and triglycerides) has shown positive outcomes. Cholesterol is a lipid categorized into LDL and HDL. Elevated serum total cholesterol and LDL levels amplify the risk of cardiovascular disease ⁶⁹^-⁷¹. HDL, conversely, is vital for stabilizing total cholesterol, as it facilitates the transport of cholesterol to the liver, where it is sequestered and eliminated. It also contributes to vascular protection by stimulating nitric oxide release and removing oxidized lipids from LDL ⁶⁹.

Elevated triglyceride levels are identified as a risk factor for cardiovascular disease, HT, and DM. Individuals with hypertri-glyceridemia (high triglyceride levels) are more prone to develop obesity, hepatic steatosis, and ectopic fat deposition ⁴⁸^,⁶⁰^,⁷²^,⁷³. For these clinical markers, the use of A. cordifolia has been shown to decrease serum triglyceride levels ²⁴^,²⁸^,³¹^,³²^,³⁹, total cholesterol levels ²⁸^,³¹^,³²^,³⁹^,⁴³, and LDL ³¹^,³²^,³⁹, in addition to increasing HDL ³¹^,³⁹. Another clinical marker, uric acid, which is a product of purine metabolism, when elevated, results in hyperuricemia, known as gout ⁷⁴. Gout is a form of inflammatory arthritis, with the most typical clinical presentation being intense acute inflammatory arthritis ⁷⁵. Moreover, there is evidence that uric acid is significantly associated with hypertension, indicating that effective management is crucial in preventing HT ⁷⁴. According to the findings of this scoping review, the plant extract exhibits an anti-hyperuricemic effect and inhibits the enzyme xanthine oxidase ⁴¹, which is responsible for converting xanthine into uric acid and thus directly relates to the quantity and rate of uric acid production ⁷⁶.

Another pathology highlighted in the studies was cataracts, characterized by the opacification of the eye's lens, leading to impaired visual acuity, which can be partial or total. The prevalence of cataracts in diabetic patients is significantly higher-two to five times-compared to the general population ⁷⁷. Additionally, it remains a leading cause of visual impairment among individuals with DM due to increased incidence and progression, as well as earlier occurrence. It is estimated that 20 % of cataract surgeries are conducted on patients with DM ⁷⁸^,⁷⁹. Regarding the therapeutic use of A. cordifolia, the plant demonstrated positive effects in an experiment on induced cataracts in goat lenses ²², where the treated lenses exhibited a lesser degree of cataract, along with a reduced concentration of malondialdehyde. Malondialdehyde, a biomarker indicative of oxidative stress, is closely linked to the development of cataracts; the higher its level, the greater the ocular lens turbidity and the cataract severity. The level reduction is presumably due to the extract's high antioxidant content ²².

After reviewing all the articles and learning about the benefits of A. cordifolia and its therapeutic potential, it is evident the plant holds promise for the production of herbal medicine. It is critical to acknowledge that scientific research has been a pivotal factor driving the increased interest in herbal medicine. There remains a need to enhance awareness about the vast biodiversity of medicinal plants in Brazil and how to access them for both the public and professionals who can offer guidance on their use ⁸⁰.

Health professionals, especially nurses, are at the forefront of recognizing PICS and play a significant role in fostering the ex change and development of new knowledge regarding medicinal plants. Nevertheless, the lack of awareness about PICS and the absence of a scientific basis for these practices are barriers to providing safe care ⁸¹. Hence, professionals must possess scientific knowledge about medicinal plants, such as A. cordifolia, and encourage ongoing scientific research into their properties, effects, and safe usage to integrate them into future care practices ⁸⁰.

Conclusions

This scoping review has facilitated the identification and mapping of evidence regarding the therapeutic properties of Anredera cordifolia in treating chronic non-communicable diseases. The compiled studies suggest that the plant may effectively treat DM, HT, CKD, obesity, and cataracts. Additionally, it has demonstrated the potential for controlling triglycerides, cholesterol, and uric acid levels.

The primary attributes identified include its hypoglycemic effects, antihypertensive activities, and ability to lower total cholesterol and triglyceride levels. It is also worth noting that Anredera cordifolia has been found to have healing properties for diabetic wounds, reduce serum creatinine levels, prevent body weight gain, and exhibit positive effects on factors directly influencing CNDs. Therefore, our findings contribute to advancing research on the therapeutic benefits of Anredera cordifolia, particularly highlighted by the urgency for further research in different geographical locations and by various researchers to validate the published research data.

Emphasizing and incorporating traditional knowledge into new research is crucial. Given the significance of medicinal plants and the positive impacts of Anredera cordifolia and its potential as a therapeutic resource in healthcare practice, further investigation in the field of nursing is suggested. This approach aims to provide a scientific foundation and support for the safe use of medicinal plants in healthcare settings.

Referências

1. Aguiar J, Kanan LA, Masiero AV. Praticas Integrativas e Complementares na atencao basica em saude: um estudo bibliometrico da producao brasileira. Saude Debate [Internet]. 2019 [acesso 7 abril 2023];43(123):1205-28. DOI: DOI: https://doi.org/10.1590/0103-1104201912318

J Aguiar LA Kanan AV Masiero Praticas Integrativas e Complementares na atencao basica em saude: um estudo bibliometrico da producao brasileiraSaude Debate20197 abril 20234312312051228 DOI: https://doi.org/10.1590/0103-1104201912318

2. Brasil. Ministerio da Saude. Praticas Integrativas e Complementares (PICS) [Internet]. Ministerio da Saude; 2020. [acesso 10 abril 2023]. Disponivel em: Disponivel em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/p/pics

Brasil. Ministerio da Saude Praticas Integrativas e Complementares (PICS)Ministerio da Saude202010 abril 2023Disponivel em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/p/pics

3. Organizacao das Nacoes Unidas (ONU). Pnuma: Brasil possui entre 15% e 20% da diversidade biologica mundial [Internet]. 2019. [acesso 8 maio 2023]. Disponivel em: Disponivel em: https://news.un.org/pt/story/2019/03/1662482

Organizacao das Nacoes Unidas (ONU) Pnuma: Brasil possui entre 15% e 20% da diversidade biologica mundial20198 maio 2023Disponivel em: https://news.un.org/pt/story/2019/03/1662482

4. Santana da Silva LW, Soares Pamponet LSP. Saberes populares no uso de plantas medicinais: tradicao de valor familiar na convergencia aos saberes cientificos. Revista REVISE [Internet]. 2022 [acesso 13 fev. 2023];9:325-51. Disponivel em: Disponivel em: https://www3.ufrb.edu.br/index.php/revise/article/view/2646/1650

LW Santana da Silva LSP Soares Pamponet Saberes populares no uso de plantas medicinais: tradicao de valor familiar na convergencia aos saberes cientificosRevista REVISE202213 fev. 20239325351Disponivel em: https://www3.ufrb.edu.br/index.php/revise/article/view/2646/1650

5. World Health Organization. Noncommunicable diseases progress monitor 2022 [Internet]. Geneva: World Health Organization; 2022 [acesso 11 mar. 2023]. Disponivel em: Disponivel em: https://iris.who.int/bitstream/handle/10665/353048/9789240047761-eng.pdf?sequence=1

World Health Organization Noncommunicable diseases progress monitor 2022GenevaWorld Health Organization202211 mar. 2023Disponivel em: https://iris.who.int/bitstream/handle/10665/353048/9789240047761-eng.pdf?sequence=1

6. Figueiredo AEB, Ceccon RF, Figueiredo JHC. Doencas cronicas nao transmissiveis e suas implicacoes na vida de idosos dependentes. Cien Saude Colet [Internet]. 2021 [acesso 8 maio 2023];26(1). DOI: DOI: https://doi.org/10.1590/1413-81232020261.33882020

AEB Figueiredo RF Ceccon JHC Figueiredo Doencas cronicas nao transmissiveis e suas implicacoes na vida de idosos dependentesCien Saude Colet20218 maio 2023261 DOI: https://doi.org/10.1590/1413-81232020261.33882020

7. Brasil. Ministerio da Saude. Secretaria de Vigilancia em Saude. Departamento de Analise em Saude e Vigilancia de Doencas Nao Transmissiveis. Plano de acoes estrategicas para o enfrentamento das doencas cronicas e agravos nao transmissiveis no Brasil 2021- 2030. Brasilia: Ministerio da Saude; 2021 [acesso 8 maio 2023]. Disponivel em: Disponivel em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/doencas-cronicas-nao-transmissiveis-dcnt/09-plano-de-dant-2022_2030.pdf/view

Brasil. Ministerio da Saude Secretaria de Vigilancia em Saude. Departamento de Analise em Saude e Vigilancia de Doencas Nao Transmissiveis. Plano de acoes estrategicas para o enfrentamento das doencas cronicas e agravos nao transmissiveis no Brasil 2021- 2030BrasiliaMinisterio da Saude20218 maio 2023Disponivel em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/doencas-cronicas-nao-transmissiveis-dcnt/09-plano-de-dant-2022_2030.pdf/view

8. Barros DM. A utilizacao de plantas medicinais no proceso terapeutico complementar das doencas cronicas nao transmissiveis. In: Pereira TT, Castro LHA, Oesterreich SA, editores. Ciencias da saude campo promissor em pesquisa. Ponta Grossa: Atena Editora; 2020. p. 22-40.

DM Barros A utilizacao de plantas medicinais no proceso terapeutico complementar das doencas cronicas nao transmissiveis TT Pereira LHA Castro SA Oesterreich Ciencias da saude campo promissor em pesquisaPonta GrossaAtena Editora20202240

9. Badke MR, Barbieri RS, Cogo SB, Essi L, Alvim NAT, da Silva RAR et al. Natural resources for therapeutic use: Evidence from Brazil. Res Rev J Nurs Health Sci [Internet]. 2021 [cited 2023 Apr 9];7(1):24-34. Disponivel em: Disponivel em: https://portal.uern.br/wp-content/uploads/2021/01/natural-resources-for-therapeutic-use-evidence-from-brazil-1.pdf

MR Badke RS Barbieri SB Cogo L Essi NAT Alvim RAR da Silva Natural resources for therapeutic use: Evidence from BrazilRes Rev J Nurs Health Sci20212023 Apr 9712434Disponivel em: https://portal.uern.br/wp-content/uploads/2021/01/natural-resources-for-therapeutic-use-evidence-from-brazil-1.pdf

10. Pellegrini MOO, Imig DC. Basellaceae in Flora do Brasil [Internet]. Jardim Botanico do Rio de Janeiro 2020 [acesso 5 fev. 2023]. Disponivel em: Disponivel em: https://floradobrasil2020.jbrj.gov.br/FB5558

MOO Pellegrini DC Imig Basellaceae in Flora do BrasilJardim Botanico do Rio de Janeiro20205 fev. 2023Disponivel em: https://floradobrasil2020.jbrj.gov.br/FB5558

11. Martinevski CS, Oliveira VR de, Rios A de O, Flores SH, Venzke JG. Utilizacao de bertalha (anredera cordifolia (ten.) Steenis) e ora-pro-nobis (pereskia aculeata mill.) na elaboracao de paes. Alimentos e Nutricao [Internet]. 2013 [acesso 5 abril 2023];24(3). Disponivel em: Disponivel em: https://doaj.org/article/6b8f3706f4ea4b1ab763fb0976393c91

CS Martinevski VR de Oliveira O Rios A de SH Flores JG Venzke Utilizacao de bertalha (anredera cordifolia (ten.) Steenis) e ora-pro-nobis (pereskia aculeata mill.) na elaboracao de paesAlimentos e Nutricao20135 abril 2023243Disponivel em: https://doaj.org/article/6b8f3706f4ea4b1ab763fb0976393c91

12. Cordeiro SZ. Anredera cordifolia (Ten.) Steenis [Internet]. Universidade Federal do Estado do Rio de Janeiro. 2021 [acesso 4 jan. 2023]. Disponivel em: Disponivel em: https://www.unirio.br/ccbs/ibio/herbariohuni/anredera-cordifolia-ten-steenis

SZ Cordeiro Anredera cordifolia (Ten.) SteenisUniversidade Federal do Estado do Rio de Janeiro20214 jan. 2023Disponivel em: https://www.unirio.br/ccbs/ibio/herbariohuni/anredera-cordifolia-ten-steenis

13. Heisler EV, Badke MR, Andrade A, Rodrigues MGS. Saber popular sobre a utilizacao da planta Anredera cordifolia (folha gorda) [Internet]. Texto & contexto enferm. 2012 [acesso 5 fev. 2023];21(4):937-44. DOI: DOI: https://doi.org/10.1590/S0104-07072012000400026

EV Heisler MR Badke A Andrade MGS Rodrigues Saber popular sobre a utilizacao da planta Anredera cordifolia (folha gorda)Texto & contexto enferm20125 fev. 2023214937944 DOI: https://doi.org/10.1590/S0104-07072012000400026

14. Kinupp VF, Amaro FS, Barros IBI. Anredera cordifolia (Basellaceae), uma hortalica potencial em desuso no Brasil [Internet]. 2013. [acesso 5 fev. 2023]. Disponivel em: Disponivel em: https://ssmfoto.files.wordpress.com/2012/08/kinupp-amaro-barros_2004_anredera.pdf

VF Kinupp FS Amaro IBI Barros Anredera cordifolia (Basellaceae), uma hortalica potencial em desuso no Brasil20135 fev. 2023Disponivel em: https://ssmfoto.files.wordpress.com/2012/08/kinupp-amaro-barros_2004_anredera.pdf

15. Nxumalo CI, Ngidi LS, Shandu JSE, Maliehe TS. Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities [Internet]. BMC Complementary Med Ther. 2020 [cited 2023 Mar 4];20(300). DOI: DOI: https://doi.org/10.1186/s12906-020-03095-z

CI Nxumalo LS Ngidi JSE Shandu TS Maliehe Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activitiesBMC Complementary Med Ther20202023 Mar 420300 DOI: https://doi.org/10.1186/s12906-020-03095-z

16. Souza LF, de Barros IBI, Mancini E, Martino LD, Scandolera E, Feo VD. Chemical composition and biological activities of the essential oil from Anredera cordifolia grown in Brazil [Internet]. Nat Prod Commun. 2014 [cited 2023 Apr 5];9(7):1003-1006. Disponivel em: Disponivel em: https://journals.sagepub.com/doi/epdf/10.1177/1934578X1400900730

LF Souza IBI de Barros E Mancini LD Martino E Scandolera VD Feo Chemical composition and biological activities of the essential oil from Anredera cordifolia grown in BrazilNat Prod Commun20142023 Apr 59710031006Disponivel em: https://journals.sagepub.com/doi/epdf/10.1177/1934578X1400900730

17. Yuniarti WM, Lukiswanto BS. Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino rats [Internet]. Vet World. 2017 [cited 2023 Apr 24];10(7):808-13. DOI: DOI: https://doi.org/10.14202/vetworld.2017.808-813

WM Yuniarti BS Lukiswanto Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino ratsVet World20172023 Apr 24107808813 DOI: https://doi.org/10.14202/vetworld.2017.808-813

18. JBI Manual for Evidence Synthesis [Internet]. The Joanna Briggs Institute. 2020 [cited 2022 Feb 19]. Disponivel em: Disponivel em: https://jbi-global-wiki.refined.site/space/MANUAL

JBI Manual for Evidence SynthesisThe Joanna Briggs Institute20202022 Feb 19Disponivel em: https://jbi-global-wiki.refined.site/space/MANUAL

19. Munn Z, Pollock D, Khalil H, Alexander L, McInerney P, Godfrey CM et al. What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesis [Internet]. JBI Evid Synth. 2022 [acesso 29 fev. 2022];20(4):950-2. DOI: DOI: https://doi.org/10.11124/JBIES-21-00483

Z Munn D Pollock H Khalil L Alexander P McInerney CM Godfrey What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesisJBI Evid Synth202229 fev. 2022204950952 DOI: https://doi.org/10.11124/JBIES-21-00483

20. Bardin L. Analise de conteudo. Reto LA, Pinheiro A, tradutores. Sao Paulo: Edicoes 70; 2016.

L Bardin Analise de conteudo. Reto LA, Pinheiro A, tradutoresSao PauloEdicoes 702016

21. Dwitiyanti D, Harahap Y, Elya B, Bahtiar A. Binahong (Anredera cordifolia (Tenore) Steen.) leaf extract modulates fatty acids and amino acids to lower blood glucose in high-fat diet-induced diabetes mellitus rats [Internet]. Adv Pharmacol Pharm Sci. 2021 [acesso 14 jun. 2022];2021:e8869571. DOI: DOI: https://doi.org/10.1155/2021/8869571

D Dwitiyanti Y Harahap B Elya A Bahtiar Binahong (Anredera cordifolia (Tenore) Steen.) leaf extract modulates fatty acids and amino acids to lower blood glucose in high-fat diet-induced diabetes mellitus ratsAdv Pharmacol Pharm Sci202114 jun. 20222021e8869571 DOI: https://doi.org/10.1155/2021/8869571

22. Feriyani F, Maulanza H, Lubis RR, Balqis U, Darmawi D. Effects of Binahong (Anredera cordifolia (Tenore) Steenis) extracts on the levels of malondialdehyde (MDA) in cataract goat lenses [Internet]. Scientific World Journal. 2021 [cited 2022 Jun 14];2021:e661792. DOI: DOI: https://doi.org/10.1155/2021/6617292

F Feriyani H Maulanza RR Lubis U Balqis D Darmawi Effects of Binahong (Anredera cordifolia (Tenore) Steenis) extracts on the levels of malondialdehyde (MDA) in cataract goat lensesScientific World Journal20212022 Jun 142021e661792 DOI: https://doi.org/10.1155/2021/6617292

23. Sukandar E, Suliska N, Suryani, Insanu M. Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine induced male Wistar rat [Internet]. J Adv Pharm Technol Res. 2021 [cited 2022 Jun 14];12(4):384. Disponivel em: Disponivel em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588926/

Suliska N Sukandar E Insanu M Suryani Antihypertensive activity of combination of anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. leaves on Epinephrine induced male Wistar ratJ Adv Pharm Technol Res20212022 Jun 14124384384Disponivel em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588926/

24. Hashimoto M, Matsuzaki K, Maruyama K, Sumiyoshi E, Hossain S, Wakatsuki H et al. Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: A possible supplement for brain health [Internet]. Food Funct. 2022 [cited 2022 Jun 15];13(13):7226-39. DOI: DOI: https://doi.org/10.1039/D2FO00723A

M Hashimoto K Matsuzaki K Maruyama E Sumiyoshi S Hossain H Wakatsuki Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: A possible supplement for brain healthFood Funct20222022 Jun 15131372267239 DOI: https://doi.org/10.1039/D2FO00723A

25. Sukandar EY, Fidrianny I, Adiwibowo LF. Efficacy of etanol extract of Anredera cordifolia (Ten) Steenis leaves on improving kidney failure in rats [Internet]. Int J Pharmacol. 2011 [cited 2023 Feb 13];1;7(8):850-5. DOI: DOI: https://doi.org/10.3923/ijp.2011.850.855

EY Sukandar I Fidrianny LF Adiwibowo Efficacy of etanol extract of Anredera cordifolia (Ten) Steenis leaves on improving kidney failure in ratsInt J Pharmacol20112023 Feb 1378850855 DOI: https://doi.org/10.3923/ijp.2011.850.855

26. Sukandar EY, Garmana AN, Aidasari AU, Crystalia AA. Antihypertensive activity of ethanol extract combination of Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L. leaves on angiotensin II- induced male wistar rat [Internet]. J Res Pharm. 2019 [cited 2023 Feb 13];15;23(6):1090-7. Disponivel em: Disponivel em: https://jrespharm.com/uploads/pdf/pdf_MPJ_747.pdf

EY Sukandar AN Garmana AU Aidasari AA Crystalia Antihypertensive activity of ethanol extract combination of Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L. leaves on angiotensin II- induced male wistar ratJ Res Pharm20192023 Feb 1323610901097Disponivel em: https://jrespharm.com/uploads/pdf/pdf_MPJ_747.pdf

27. Sukandar EY, Sigit JI, Adiwibowo LF. Study of kidney repair mechanisms of corn silk (Zea mays L. Hair)-Binahong (Anredera cordifolia (Ten.) Steenis) leaves combination in rat model of kidney failure [Internet]. Int J Pharmacol. 2013 [cited 2023 Feb 13];9(1):12-23. DOI: DOI: https://doi.org/10.3923/ijp.2013.12.23

EY Sukandar JI Sigit LF Adiwibowo Study of kidney repair mechanisms of corn silk (Zea mays L. Hair)-Binahong (Anredera cordifolia (Ten.) Steenis) leaves combination in rat model of kidney failureInt J Pharmacol20132023 Feb 13911223 DOI: https://doi.org/10.3923/ijp.2013.12.23

28. Dwitiyanti, Rorenza T. The Effect of 96 % Ethanol extract of Binahong leaf on hyperglycemia white male rats using total cholesterol and triglyceride parameters [Internet]. IOP Conf Ser Earth Environ Sci. 2021 [cited 2023 Feb 13];1;755(1):012005. DOI: DOI: https://doi.org/10.1088/1755-1315/755/1/012005

Rorenza T Dwitiyanti The Effect of 96 % Ethanol extract of Binahong leaf on hyperglycemia white male rats using total cholesterol and triglyceride parametersIOP Conf Ser Earth Environ Sci20212023 Feb 137551012005012005 DOI: https://doi.org/10.1088/1755-1315/755/1/012005

29. Bahtiar A, Utami PS, Noor MR. The antioxidant effects of the ethanolic extract of Binahong leaves unilateral ureteral obstruction rat model [Internet]. Pharmacogn J. 2021 [cited 2023 Feb 13];13(1):185-8. DOI: DOI: https://doi.org/10.5530/pj.2021.13.26

A Bahtiar PS Utami MR Noor The antioxidant effects of the ethanolic extract of Binahong leaves unilateral ureteral obstruction rat modelPharmacogn J20212023 Feb 13131185188 DOI: https://doi.org/10.5530/pj.2021.13.26

30. Garmana AN, Sukandar EY, Fidrianny I. Preliminary study of blood pressure lowering effect of Anredera cordifolia (Ten.) Steenis) on Wistar rats [Internet]. Int J Pharmacogn Phytochem Res. 2016 [cited 2023 Feb 13];8(2);300-4. Disponivel em: Disponivel em: https://www.researchgate.net/publication/298090613

AN Garmana EY Sukandar I Fidrianny Preliminary study of blood pressure lowering effect of Anredera cordifolia (Ten.) Steenis) on Wistar ratsInt J Pharmacogn Phytochem Res20162023 Feb 1382300304Disponivel em: https://www.researchgate.net/publication/298090613

31. Lestari D, Sukandar EY, Fidrianny I. Anredera cordifolia leaves fraction as an antihyperlipidemia [Internet]. Asian J Pharm Clin Res. 2016 [cited 2023 Feb 13];9(6):82-4. DOI: DOI: https://doi.org/10.22159/ajpcr.2016.v9i6.13628

D Lestari EY Sukandar I Fidrianny Anredera cordifolia leaves fraction as an antihyperlipidemiaAsian J Pharm Clin Res20162023 Feb 13968284 DOI: https://doi.org/10.22159/ajpcr.2016.v9i6.13628

32. Sukandar EY, Safitri D, Aini NN. The study of ethanolic extract of binahong leaves (anredera cordifolia [ten.] Steenis) and mulberry leaves (morus nigra l.) In combination on hyperlipidemic- induced rats [Internet]. Asian J Pharm Clin Res. 2016 [cited 2023 Feb 13];9(6):288-92. DOI: DOI: https://doi.org/10.22159/ajpcr.2016.v9i6.14412

EY Sukandar D Safitri NN Aini The study of ethanolic extract of binahong leaves (anredera cordifolia [ten.] Steenis) and mulberry leaves (morus nigra l.) In combination on hyperlipidemic- induced ratsAsian J Pharm Clin Res20162023 Feb 1396288292 DOI: https://doi.org/10.22159/ajpcr.2016.v9i6.14412

33. Sutrisno E, Sukandar EY, Fidrianny I, Adnyana IK. Wound healing in vivo and in vitro study of binahong leaves (anredera cordifolia (ten.) Steenis) and pegagan (centella asiatica (l.) Urban) ethanolic extract [Internet]. Pharmacologyonline. 2018 [cited 2023 Feb 13];112:111-6. Disponivel em: Disponivel em: https://pharmacologyonline.silae.it/files/archives/2018/vol1/PhOL_2018_1_A012_Sutrisno.pdf

E Sutrisno EY Sukandar I Fidrianny IK Adnyana Wound healing in vivo and in vitro study of binahong leaves (anredera cordifolia (ten.) Steenis) and pegagan (centella asiatica (l.) Urban) ethanolic extractPharmacologyonline20182023 Feb 13112111116Disponivel em: https://pharmacologyonline.silae.it/files/archives/2018/vol1/PhOL_2018_1_A012_Sutrisno.pdf

34. Wahjuni S, Rustini NL, Putri L. Effects of Binahong (Anredera Cordifolia) Leaf ethanol extracts on blood glucose levels and pancreas histopathology in hyperglycemic rats [Internet]. JGPT. 2019 [cited 2023 Feb 14];11(4):437-42. Disponivel em: Disponivel em: https://erepo.unud.ac.id/id/eprint/29258/1/ccf668d0e69b1d873397b8694bbd62a3.pdf

S Wahjuni NL Rustini L Putri Effects of Binahong (Anredera Cordifolia) Leaf ethanol extracts on blood glucose levels and pancreas histopathology in hyperglycemic ratsJGPT20192023 Feb 14114437442Disponivel em: https://erepo.unud.ac.id/id/eprint/29258/1/ccf668d0e69b1d873397b8694bbd62a3.pdf

35. Sukandar EY, Kurniati NF, Nurdianti AN. Antiobesity effect of ethanol extract of anredera cordifolia (ten) steenis leaves on obese male wistar rats induced by high-carbohydrate diet [Internet]. Int J Pharm Pharm Sci. 2016 [cited 2023 Feb 14];8(4):171-3. Disponivel em: Disponivel em: https://journals.innovareacademics.in/index.php/ijpps/article/view/10083

EY Sukandar NF Kurniati AN Nurdianti Antiobesity effect of ethanol extract of anredera cordifolia (ten) steenis leaves on obese male wistar rats induced by high-carbohydrate dietInt J Pharm Pharm Sci20162023 Feb 1484171173Disponivel em: https://journals.innovareacademics.in/index.php/ijpps/article/view/10083

36. Djamil R, Winarti W, Zaidan S, Abdillah S. Antidiabetic activity of flavonoid from Binahong leaves (Anredera cordifolia) extract in Alloxan induced mice [Internet]. J Pharmacogn Nat Prod. 2017 [cited 2023 Feb 14];3(2):e1000139. DOI: DOI: https://doi.org/10.4172/2472-0992.1000139

R Djamil W Winarti S Zaidan S Abdillah Antidiabetic activity of flavonoid from Binahong leaves (Anredera cordifolia) extract in Alloxan induced miceJ Pharmacogn Nat Prod20172023 Feb 1432e1000139 DOI: https://doi.org/10.4172/2472-0992.1000139

37. Garmana AN, Sukandar EY, Fidrianny I. Antihypertension study of Anredera cordifolia (ten). V. Steenis extract and its fractions in rats through dexamethasone induction and nitricoxide release [Internet]. Asian J Pharm Clin Res. 2018 [cited 2023 Feb 15];11(1):278-82. DOI: DOI: https://doi.org/10.22159/ajpcr.2018.v11i1.22312

AN Garmana EY Sukandar I Fidrianny Antihypertension study of Anredera cordifolia (ten). V. Steenis extract and its fractions in rats through dexamethasone induction and nitricoxide releaseAsian J Pharm Clin Res20182023 Feb 15111278282 DOI: https://doi.org/10.22159/ajpcr.2018.v11i1.22312

38. Kintoko, Desmayanti A. The effectivity of ethanolic extract of Binahong leaves (Anredera cordifolia (tenore) steen) gel in the management of diabetic wound healing in aloxan-induced rat models [Internet]. JKKI. 2016 [cited 2023 Feb 15];7(5):227-36. DOI: DOI: https://doi.org/10.20885/JKKI.Vol7.Iss5.art9

Desmayanti A Kintoko The effectivity of ethanolic extract of Binahong leaves (Anredera cordifolia (tenore) steen) gel in the management of diabetic wound healing in aloxan-induced rat modelsJKKI20162023 Feb 1575227236 DOI: https://doi.org/10.20885/JKKI.Vol7.Iss5.art9

39. Lestari D, Sukandar EY, Fidrianny I. Anredera cordifolia leaves extract as Antihyperlipidemia and Endothelial fat content reducer in male Wistar rat [Internet]. Int J Pharm Clin Res. 2015 [cited 2023 Feb 13];7(6):435-39. Disponivel em: Disponivel em: https://impactfactor.org/PDF/IJPCR/7/IJPCR,Vol7,Issue6,Article11.pdf

D Lestari EY Sukandar I Fidrianny Anredera cordifolia leaves extract as Antihyperlipidemia and Endothelial fat content reducer in male Wistar ratInt J Pharm Clin Res20152023 Feb 1376435439Disponivel em: https://impactfactor.org/PDF/IJPCR/7/IJPCR,Vol7,Issue6,Article11.pdf

40. Sukandar EY, Ridwan A, Sukmawan YP. Vasodilatation effect of ethanolic extract of anredera cordifolia, sonchus arvensis l, and ursolic acid on isolated rabbit aortic and frog heart [Internet]. Int J Pharm Pharm Sci. 2016 [cited 2023 Feb 18];8(2):145-9. Disponivel em: Disponivel em: https://journals.innovareacademics.in/index.php/ijpps/article/view/9653

EY Sukandar A Ridwan YP Sukmawan Vasodilatation effect of ethanolic extract of anredera cordifolia, sonchus arvensis l, and ursolic acid on isolated rabbit aortic and frog heartInt J Pharm Pharm Sci20162023 Feb 1882145149Disponivel em: https://journals.innovareacademics.in/index.php/ijpps/article/view/9653

41. Widyarini KD, Sukandar EY, Fidrianny I. Xanthine oxidase inhibitory and antihyperuricemic activities of Anredera cordifolia (ten) steenis, sonchus arvensis l, and its combination [Internet]. Int J Pharm Pharm Sci. 2015 [cited 2023 Feb 13];7(3):86-90. Disponivel em: Disponivel em: https://impactfactor.org/PDF/IJPPR/8/IJPPR,Vol8,Issue2,Article15.pdf

KD Widyarini EY Sukandar I Fidrianny Xanthine oxidase inhibitory and antihyperuricemic activities of Anredera cordifolia (ten) steenis, sonchus arvensis l, and its combinationInt J Pharm Pharm Sci20152023 Feb 13738690Disponivel em: https://impactfactor.org/PDF/IJPPR/8/IJPPR,Vol8,Issue2,Article15.pdf

42. Astuti SM, Sakinah AMM, Risch A. The triterpenoid saponin from Binahong [Anredera cordifolia (Ten) Steenis] to potential using as antidiabetic activity in animal laboratory. [Internet]. Proceeding of International Conference on Drug Development of Natural Resources. 2012 [cited 2023 Feb 13]. Disponivel em: Disponivel em: http://devel.uad.ac.id/farmasi/wp-content/uploads/52-The-Triterpenoid-Saponin-From-Binahong-...pdf

SM Astuti AMM Sakinah A Risch The triterpenoid saponin from Binahong [Anredera cordifolia (Ten) Steenis] to potential using as antidiabetic activity in animal laboratoryProceeding of International Conference on Drug Development of Natural Resources20122023 Feb 13Disponivel em: http://devel.uad.ac.id/farmasi/wp-content/uploads/52-The-Triterpenoid-Saponin-From-Binahong-...pdf

43. Wahjuni S. Anti-hyperchloesterolmia of Anredera cordifolia in hypercholesterolemic Wistar rats through malondialdehyde and 8-hydroxy-diguanosine [Internet]. InaBJ. 2014 [cited 2023 Feb 14];16;8(1):4. DOI: DOI: https://doi.org/10.15562/ijbs.v8i1.7

S Wahjuni Anti-hyperchloesterolmia of Anredera cordifolia in hypercholesterolemic Wistar rats through malondialdehyde and 8-hydroxy-diguanosineInaBJ20142023 Feb 148144 DOI: https://doi.org/10.15562/ijbs.v8i1.7

44. Sukandar EY, Ridwan A, Sukmawan YP. Vasodilatation effect of ethanolic extract of anredera cordifolia, sonchus arvensis l, and ursolic acid on isolated rabbit aortic and frog heart [Internet]. Int J Pharm Pharm Sci. 2016 [cited 2023 Feb 10];8(2):145-9. Disponivel em: Disponivel em: https://journals.innovareacademics.in/index.php/ijpps/article/view/9653

EY Sukandar A Ridwan YP Sukmawan Vasodilatation effect of ethanolic extract of anredera cordifolia, sonchus arvensis l, and ursolic acid on isolated rabbit aortic and frog heartInt J Pharm Pharm Sci20162023 Feb 1082145149Disponivel em: https://journals.innovareacademics.in/index.php/ijpps/article/view/9653

45. Sukandar EY, Qowiyyah A, Larasari L. Effect of metanol extract hearhleaf madeiravine (anredera cordifolia (ten.) steenis) leaves on blood sugar in diabetes mellitus model mice [Internet]. Jurnal Medika Planta. 2011 [cited 2023 Feb 14];1(4). Disponivel em: Disponivel em: https://www.neliti.com/publications/245773/effect-of-methanol-extract-hearhleaf-madeiravine-anredera-cordifolia-ten-steenis - id-section-content

EY Sukandar A Qowiyyah L Larasari Effect of metanol extract hearhleaf madeiravine (anredera cordifolia (ten.) steenis) leaves on blood sugar in diabetes mellitus model miceJurnal Medika Planta20112023 Feb 1414Disponivel em: https://www.neliti.com/publications/245773/effect-of-methanol-extract-hearhleaf-madeiravine-anredera-cordifolia-ten-steenis - id-section-content

46. Kusriani H, Susilawati E, Nurafipah L, Nurkholifah. Antidiabetic activity of combination of Binahong (Anredera cordifolia Ten. Steenis), Cherry (Muntingia calabura L.) and Brotowali (Tinospora crispa L.) Extracts [Internet]. J Pharm Bioallied Sci. 2023 [cited 2023 Feb 14];15(2):75-80. DOI: DOI: https://doi.org/10.4103/jpbs.jpbs_917_21

H Kusriani E Susilawati L Nurafipah Nurkholifah Antidiabetic activity of combination of Binahong (Anredera cordifolia Ten. Steenis), Cherry (Muntingia calabura L.) and Brotowali (Tinospora crispa L.) ExtractsJ Pharm Bioallied Sci20232023 Feb 141527580 DOI: https://doi.org/10.4103/jpbs.jpbs_917_21

47. Sulfianti A, Firdausi N, Nurhadi N, Ngatinem N, Agustini K, Ningsih S. Antidiabetic activity of Anredera cordifolia (Ten.) Stennis extracts with different ethanol percentages: An evaluation based on in vitro, in vivo, and molecular studies [Internet]. Pharmacia. 2023 [cited 2023 Feb 14];70(1):39-47. DOI: DOI: https://doi.org/10.3897/pharmacia.70.e94899

A Sulfianti N Firdausi N Nurhadi N Ngatinem K Agustini S Ningsih Antidiabetic activity of Anredera cordifolia (Ten.) Stennis extracts with different ethanol percentages: An evaluation based on in vitro, in vivo, and molecular studiesPharmacia20232023 Feb 147013947 DOI: https://doi.org/10.3897/pharmacia.70.e94899

48. Tomaz PA, Silva Junior WF da. Medicamentos fitoterapicos utilizados no tratamento de doencas cronicas nao transmissiveis [Internet]. Res Soc Dev. 2022 [acesso 15 fev. 2023];11(10):e439111033036. DOI: DOI: https://doi.org/10.33448/rsd-v11i10.33036

PA Tomaz WF da Silva Junior Medicamentos fitoterapicos utilizados no tratamento de doencas cronicas nao transmissiveisRes Soc De202215 fev. 20231110e439111033036 DOI: https://doi.org/10.33448/rsd-v11i10.33036

49. Brasil. Ministerio da Saude. Agencia Nacional de Vigilancia Sanitaria. Instrucao Normativa N° 2 de 13 de maio de 2014 [Internet]. Brasilia: Ministerio da Saude; 2014. Disponivel em: https://fitoterapiabrasil.com.br/sites/default/files/legislacao/in_02_2014.pdf

Brasil. Ministerio da Saude Agencia Nacional de Vigilancia Sanitaria. Instrucao Normativa N° 2 de 13 de maio de 2014BrasiliaMinisterio da Saude2014https://fitoterapiabrasil.com.br/sites/default/files/legislacao/in_02_2014.pdf

50. International Diabetes Federation Diabetes atlas 10TH edition - Home [Internet]. Diabetesatlas.org. 2021 [cited 2022 Nov 17]. Disponivel em: Disponivel em: https://diabetesatlas.org/atlas/tenth-edition/

International Diabetes Federation Diabetes atlas 10TH edition - HomeDiabetesatlas.org20212022 Nov 17Disponivel em: https://diabetesatlas.org/atlas/tenth-edition/

51. Sociedade Brasileira de Diabetes. Diretrizes sociedade brasileira de diabetes 2019-2020 [Internet]. 2019 [acesso 17 nov. 2022]. Disponivel em: Disponivel em: http://www.saude.ba.gov.br/wp-content/uploads/2020/02/Diretrizes-Sociedade-Brasileira-de-Diabetes-2019-2020.pdf

Sociedade Brasileira de Diabetes Diretrizes sociedade brasileira de diabetes 2019-2020201917 nov. 2022Disponivel em: http://www.saude.ba.gov.br/wp-content/uploads/2020/02/Diretrizes-Sociedade-Brasileira-de-Diabetes-2019-2020.pdf

52. Bertoluci MC, Forti AC e, Pititto B de A, Vancea DMM, Malerbi FEK, Valente F et al. Diretriz Oficial da Sociedade Brasileira de Diabetes [Internet]. 2023 [acesso 10 jan. 2023]. DOI: DOI: https://doi.org/10.29327/557753

MC Bertoluci AC e Forti A Pititto B de DMM Vancea FEK Malerbi F Valente Diretriz Oficial da Sociedade Brasileira de Diabetes202310 jan. 2023 DOI: https://doi.org/10.29327/557753

53. Nascimento TM. Importancia das proteinas na nutricao humana - teoria e pratica para ensino medio [Trabalho de conclusao de curso]. Assis: Fundacao Educacional do Municipio de Assis; 2010 [acesso 15 abr. 2023]. Disponivel em: Disponivel em: https://cepein.femanet.com.br/BDigital/arqTccs/0711290031.pdf

TM Nascimento Importancia das proteinas na nutricao humana - teoria e pratica para ensino medioTrabalho de conclusao de cursoAssisFundacao Educacional do Municipio de Assis201015 abr. 2023Disponivel em: https://cepein.femanet.com.br/BDigital/arqTccs/0711290031.pdf

54. Caletti G, Bock PM. Acao do aminoacido taurina no diabetes mellitus [Internet]. Rev. bras. nutr. clin. 2009 [acesso 23 abril 2023];25(3):243-50. Disponivel em: Disponivel em: http://www.braspen.com.br/home/wp-content/uploads/2016/12/12-Acao-do-aminoacido-taurina-no-diabetes-mellitus.pdf

G Caletti PM Bock Acao do aminoacido taurina no diabetes mellitusRev. bras. nutr. clin200923 abril 2023253243250Disponivel em: http://www.braspen.com.br/home/wp-content/uploads/2016/12/12-Acao-do-aminoacido-taurina-no-diabetes-mellitus.pdf

55. Simonard H, Maia SG, Gon GW, Grimm KS, Rosa GCB. Papel da suplementacao de taurina em pacientes diabeticos [Trabalho de conclusao de curso]. Joinville: Centro Universitario SOCIESC; 2021 [acesso 16 abr. 2023]. Disponivel: Disponivel: https://repositorio.animaeducacao.com.br/handle/ANIMA/20477

H Simonard SG Maia GW Gon KS Grimm GCB Rosa Papel da suplementacao de taurina em pacientes diabeticosTrabalho de conclusao de cursoJoinvilleCentro Universitario SOCIESC202116 abr. 2023Disponivel: https://repositorio.animaeducacao.com.br/handle/ANIMA/20477

56. Muzy J, Campos MR, Emmerick I, Silva RS da, Schramm JM de A. Prevalencia de diabetes mellitus e suas complicacoes e caracterizacao das lacunas na atencao a saude a partir da triangulacao de pesquisas [Internet]. Cad. Saude Publica. 2021 [acesso 23 fev. 2023];37(5):e00076120. DOI: DOI: https://doi.org/10.1590/0102-311x00076120

J Muzy MR Campos I Emmerick RS da Silva A Schramm JM de Prevalencia de diabetes mellitus e suas complicacoes e caracterizacao das lacunas na atencao a saude a partir da triangulacao de pesquisasCad. Saude Publica202123 fev. 2023375e00076120 DOI: https://doi.org/10.1590/0102-311x00076120

57. Clark RA, Ghosh K, Tonnesen MG. Tissue engineering for cutaneous wounds [Internet]. J Invest Dermatol. 2007 [cited 2023 Mar 14];127(5):1018-29. DOI: DOI: https://doi.org/10.1038/sj.jid.5700715

RA Clark K Ghosh MG Tonnesen Tissue engineering for cutaneous woundsJ Invest Dermatol20072023 Mar 14127510181029 DOI: https://doi.org/10.1038/sj.jid.5700715

58. Giestas S, Giestas A, Agostinho C. Doenca hepatica e diabetes mellitus: uma relacao bi-direcional [Internet]. RPD. 2015 [acesso 15 mar. 2023];10(4):158-66. Disponivel em: Disponivel em: http://www.revportdiabetes.com/wp-content/uploads/2017/11/RPD-Vol-10-n.-4-Dezembro-2015-Artigo-de-Revisao-pags-158-166.pdf

S Giestas A Giestas C. Agostinho Doenca hepatica e diabetes mellitus: uma relacao bi-direcionalRPD201515 mar. 2023104158166Disponivel em: http://www.revportdiabetes.com/wp-content/uploads/2017/11/RPD-Vol-10-n.-4-Dezembro-2015-Artigo-de-Revisao-pags-158-166.pdf

59. Martinez H, Morin C, Gandy J. Fluid intake of Latin American adults: Results from four 2016 Liq In surveys in 7 national cross-sectional surveys [Internet]. Eur J Nutr. 2018 [cited 2023 Mar 15];57:65-75. DOI: DOI: https://doi.org/10.1007/s00394-018-1724-z

H Martinez C Morin J Gandy Fluid intake of Latin American adults: Results from four 2016 Liq In surveys in 7 national cross-sectional surveysEur J Nutr20182023 Mar 15576575 DOI: https://doi.org/10.1007/s00394-018-1724-z

60. Barroso WKS, Rodrigues CIS, Bortolotto LA, Mota-Gomes MA, Brandao AA, Feitosa AD de M et al. Diretrizes Brasileiras de Hipertensao Arterial - 2020 [Internet]. Arq Bras Cardiol. 2021 [acesso 15 mar. 2023];116(3):516-658. Disponivel em: Disponivel em: http://departamentos.cardiol.br/sbc-dha/profissional/pdf/Diretriz-HAS-2020.pdf

WKS Barroso CIS Rodrigues LA Bortolotto MA Mota-Gomes AA Brandao M Feitosa AD de Diretrizes Brasileiras de Hipertensao Arterial - 2020Arq Bras Cardiol202115 mar. 20231163516658Disponivel em: http://departamentos.cardiol.br/sbc-dha/profissional/pdf/Diretriz-HAS-2020.pdf

61. Rubio TA. Frequencia cardiaca na hipertensao: revisao e opiniao do especialista [Internet]. Rev Bras Hipertens. 2019 [acesso 8 abril 2023];26(4):144-6. Disponivel em: Disponivel em: http://departamentos.cardiol.br/sbc-dha/profissional/revista/26-4/07_revista_brasileirade_hipertensao_26_n4.pdf

TA Rubio Frequencia cardiaca na hipertensao: revisao e opiniao do especialistaRev Bras Hipertens20198 abril 2023264144146Disponivel em: http://departamentos.cardiol.br/sbc-dha/profissional/revista/26-4/07_revista_brasileirade_hipertensao_26_n4.pdf

62. Guerra ALN, Araujo SRN. Oxido nitrico no controle da hipertensao arterial sistemica: uma revisao de literatura [Trabalho de conclusao de curso]. Brasilia: Universidade Catolica de Brasilia; 2013 [acesso 23 mar. 2023]. Disponivel em: Disponivel em: https://repositorio.ucb.br:9443/jspui/bitstream/123456789/8601/1/AdrianeLopodo-NascimentoGuerraTCCGraduacao2013.pdf

ALN Guerra SRN Araujo Oxido nitrico no controle da hipertensao arterial sistemica: uma revisao de literaturaTrabalho de conclusao de cursoBrasiliaUniversidade Catolica de Brasilia201323 mar. 2023Disponivel em: https://repositorio.ucb.br:9443/jspui/bitstream/123456789/8601/1/AdrianeLopodo-NascimentoGuerraTCCGraduacao2013.pdf

63. Goncalves AC, Lirio PHC, Ferraz MJRB, Moreira EAM. Benefits of drug association of diuretics and angiotensin-converting enzyme inhibitors in the treatment of systemic arterial hypertension [Internet]. BJHR. 2021 [cited 2023 Mar 24];4(2):5268-80. DOI: DOI: https://doi.org/10.34119/bjhrv4n2-100

AC Goncalves PHC Lirio MJRB Ferraz EAM Moreira Benefits of drug association of diuretics and angiotensin-converting enzyme inhibitors in the treatment of systemic arterial hypertensionBJHR20212023 Mar 244252685280 DOI: https://doi.org/10.34119/bjhrv4n2-100

64. Malkina A. Doenca renal cronica [Internet]. Manuais MSD edicao para profissionais. 2022 [acesso 15 mar. 2023]. Disponivel em: Disponivel em: https://www.msdmanuals.com/pt-br/profissional/disturbios-geniturinarios/doenca-renal-cronica/doenca-renal-cronica

A Malkina Doenca renal cronicaManuais MSD edicao para profissionais202215 mar. 2023Disponivel em: https://www.msdmanuals.com/pt-br/profissional/disturbios-geniturinarios/doenca-renal-cronica/doenca-renal-cronica

65. Abensur H. Biomarcadores na Nefrologia [E-book]. Sociedade Brasileira de Nefrologia. Sao Paulo: Roche; 2011. Disponivel em: https://www.periciamedicadf.com.br/manuais/biomarcadores_na_nefrologia.pdf

H Abensur Biomarcadores na NefrologiaSociedade Brasileira de NefrologiaSao Paulo: Roche2011https://www.periciamedicadf.com.br/manuais/biomarcadores_na_nefrologia.pdf

66. Duarte F, Pessoa EA, Reis LA, Schor N, Borges FT. Priming prevent nephrotoxic acute renal failure through stimulation of antioxidant defense mechanism [Internet]. J. bras. nefrol. 2016 [acesso 23 mar. 2023];38(2):161-72. DOI: DOI: https://doi.org/10.5935/0101-2800.20160025

F Duarte EA Pessoa LA Reis N Schor FT Borges Priming prevent nephrotoxic acute renal failure through stimulation of antioxidant defense mechanismJ. bras. nefrol201623 mar. 2023382161172 DOI: https://doi.org/10.5935/0101-2800.20160025

67. Brasil. Ministerio da Saude. Secretaria de Ciencia, Tecnologia e Insumos Estrategicos. Departamento de Assistencia Farmaceutica. Politica nacional de plantas medicinais e fitoterapicos [Internet]. Brasilia: Ministerio da Saude ; 2006. Disponivel em: https://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_fitoterapicos.pdf

Brasil. Ministerio da Saude Secretaria de Ciencia, Tecnologia e Insumos Estrategicos. Departamento de Assistencia Farmaceutica. Politica nacional de plantas medicinais e fitoterapicosBrasiliaMinisterio da Saude2006https://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_fitoterapicos.pdf

68. Nilson EAF, Andrade R da CS, Brito DA de, Michele Lessa de O. Custos atribuiveis a obesidade, hipertensao e diabetes no Sistema Unico de Saude, Brasil, 2018 [Internet]. Rev. panam. salud publica. 2020 [acesso 20 abr. 2023];44(32). DOI: DOI: https://doi.org/10.26633/RPSP.2020.32

EAF Nilson CS Andrade R da DA de Brito O Michele Lessa de Custos atribuiveis a obesidade, hipertensao e diabetes no Sistema Unico de Saude, Brasil, 2018Rev. panam. salud publica202020 abr. 20234432 DOI: https://doi.org/10.26633/RPSP.2020.32

69. Kurmus O, Erkan AF, Ekici B, Aslan T, Eren M. Discordancia entre Colesterol LDL e Nao-HDL e Gravidade da Doenca Arterial Coronaria [Internet]. Arq. bras. cardiol. 2020 [acesso 20 abril 2023];114(3):469-75. DOI: DOI: https://doi.org/10.36660%-2Fabc.20190091

O Kurmus AF Erkan B Ekici T Aslan M Eren Discordancia entre Colesterol LDL e Nao-HDL e Gravidade da Doenca Arterial CoronariaArq. bras. cardiol202020 abril 20231143469475 DOI: https://doi.org/10.36660%-2Fabc.20190091

70. Malta DC, Szwarcwald CL, Machado IE, Pereira CA, Figueiredo AW, Sa ACMGN de et al. Prevalencia de colesterol total e fracoes alterados na populacao adulta brasileira: Pesquisa Nacional de Saude [Internet]. Rev. bras. epidemiol. 2019 [acesso 21 abr. 2023]; 22(2):e190005.supl.2. DOI: DOI: https://doi.org/10.1590/1980-549720190005.supl.2

DC Malta CL Szwarcwald IE Machado CA Pereira AW Figueiredo ACMGN de Sa Prevalencia de colesterol total e fracoes alterados na populacao adulta brasileira: Pesquisa Nacional de SaudeRev. bras. epidemiol201921 abr. 2023222e1900052 DOI: https://doi.org/10.1590/1980-549720190005.supl.2

71. Sa ACMGN de, Machado IE, Bernal RTI, Malta DC. Fatores associados ao LDL-Colesterol aumentado na populacao adulta brasileira: Pesquisa Nacional de Saude [Internet]. Cienc. Saude Colet. 2021 [acesso 21 abr. 2023];26(2):541-53. DOI: DOI: https://doi.org/10.1590/1413-81232021262.37102020

Machado IE Sa ACMGN de RTI Bernal DC Malta Fatores associados ao LDL-Colesterol aumentado na populacao adulta brasileira: Pesquisa Nacional de SaudeCienc. Saude Colet202121 abr. 2023262541553 DOI: https://doi.org/10.1590/1413-81232021262.37102020

72. Moura EG, Mateus KC da S, Batista PB, Bonfante ILP, Godoi EC, Santos MR dos et al. Particularidades dos diferentestecidos adiposos [Internet]. Conexoes. 2019 [acesso 15 abril 2023];17:e019019. DOI: DOI: https://doi.org/10.20396/conex.v17i0.8653471

EG Moura S Mateus KC da PB Batista ILP Bonfante EC Godoi MR dos Santos Particularidades dos diferentestecidos adipososConexoes201915 abril 202317e019019 DOI: https://doi.org/10.20396/conex.v17i0.8653471

73. Schroeder IH. Avaliacao dos niveis de triglicerideos em diferentes tempos de jejum apos alta ingesta de gordura e carboidratos [Trabalho de conclusao de curso]. Lajeado: Universidade do Vale do Taquari; 2018 [acesso 15 mar. 2023]. Disponivel em: Disponivel em: https://www.univates.br/bduserver/api/core/bitstreams/c26f-7b3e-12bf-46b2-ac7c-fa84b3b5ac55/content

IH Schroeder Avaliacao dos niveis de triglicerideos em diferentes tempos de jejum apos alta ingesta de gordura e carboidratosTrabalho de conclusao de cursoLajeadoUniversidade do Vale do Taquari201815 mar. 2023Disponivel em: https://www.univates.br/bduserver/api/core/bitstreams/c26f-7b3e-12bf-46b2-ac7c-fa84b3b5ac55/content

74. Zhu L, Zhang X, Fang Z, Jin Y, Chang W, Chen Y et al. Associacao entre acido urico serico e pre-hipertensao e hipertensao entre adultos chineses [Internet]. Arq. bras. cardiol. 2021 [acesso 17 abr. 2023];116(6):1072-8. DOI: DOI: https://doi.org/10.36660/abc.20200098

L Zhu X Zhang Z Fang Y Jin W Chang Y Chen Associacao entre acido urico serico e pre-hipertensao e hipertensao entre adultos chinesesArq. bras. cardiol202117 abr. 2023116610721078 DOI: https://doi.org/10.36660/abc.20200098

75. Azevedo VF, Lopes MP, Catholino NM, Paiva E dos S, Araujo VA, Pinheiro G da RC. Revisao critica do tratamento medicamentoso da gota no Brasil [Internet]. Rev. bras. reumatol. 2017 [acesso 15 abr. 2023];57(4):346-55. DOI: DOI: https://doi.org/10.1016/j.rbre.2017.03.002

VF Azevedo MP Lopes NM Catholino S Paiva E dos VA Araujo RC Pinheiro G da Revisao critica do tratamento medicamentoso da gota no BrasilRev. bras. reumatol201715 abr. 2023574346355 DOI: https://doi.org/10.1016/j.rbre.2017.03.002

76. Medeiros IG, Silva C, Alcoforado I. Xantina e xantina oxidase do acido urico a gota. Rev. trab. academ. Univer. Recife. [Internet]. 2017 [acesso 20 abr. 2023];4(2). Disponivel em: Disponivel em: http://revista.universo.edu.br/index.php?journal=1UNICARECIFE2&page=article&op=viewArticle&path%5B%5D=5827

IG Medeiros C Silva I Alcoforado Xantina e xantina oxidase do acido urico a gotaRev. trab. academ. Univer. Recife201720 abr. 202342Disponivel em: http://revista.universo.edu.br/index.php?journal=1UNICARECIFE2&page=article&op=viewArticle&path%5B%5D=5827

77. Serra TCS, De Paula ACN, Amorim ACC, Cardoso DD, Rocha FP, Dos Santos LR, et al. Associacao entre catarata e diabetes: epidemiologia, fisiopatologia e principais complicacoes pos-operatorias [Internet]. Braz J Dev. 2022 [acesso 20 abr. 2023]; 8(5):34269-80. DOI: DOI: https://doi.org/10.34117/bjdv8n5-106

TCS Serra ACN De Paula ACC Amorim DD Cardoso FP Rocha LR Dos Santos Associacao entre catarata e diabetes: epidemiologia, fisiopatologia e principais complicacoes pos-operatoriasBraz J Dev202220 abr. 2023853426934280 DOI: https://doi.org/10.34117/bjdv8n5-106

78. Labetoulle M, Behndig A, Tassignon M-J, Nuijts R, Mencucci R, Guell JL et al. Safety and efficacy of a standardized intracameral combination of mydriatics and anesthetic for cataract surgery in type-2 diabetic patients [Internet]. BMC Ophthalmol. 2020 [acesso 20 abr. 2023];20(81). DOI: DOI: https://doi.org/10.1186/s12886-020-01343-x

M Labetoulle A Behndig M-J Tassignon R Nuijts R Mencucci JL Guell Safety and efficacy of a standardized intracameral combination of mydriatics and anesthetic for cataract surgery in type-2 diabetic patientsBMC Ophthalmol202020 abr. 20232081 DOI: https://doi.org/10.1186/s12886-020-01343-x

79. Naderi K, Gormley J, O’Brart D. Cataract surgery and dry eye disease: A review [Internet]. Eur J Ophthalmol. 2020 [acesso 21 abr. 2023];30(5):840-55. DOI: DOI: https://doi.org/10.1177/1120672120929958

K Naderi J Gormley D O’Brart Cataract surgery and dry eye disease: A reviewEur J Ophthalmol202021 abr. 2023305840855 DOI: https://doi.org/10.1177/1120672120929958

80. Ferreira ET, Santos ES, Monteiro JS, Gomes MSM, Menezes RAO, Souza MJC. A utilizacao de plantas medicinais e fitoterapicos: uma revisao integrativa sobre a atuacao do enfermeiro [Internet]. BJHR. 2019 [acesso 20 abr. 2023];2(3):1511-23. Disponivel em: Disponivel em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/1383

ET Ferreira ES Santos JS Monteiro MSM Gomes RAO Menezes MJC Souza A utilizacao de plantas medicinais e fitoterapicos: uma revisao integrativa sobre a atuacao do enfermeiroBJHR201920 abr. 20232315111523Disponivel em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/1383

81. Soares DP, Coelho AM, Silva LEA da, Silva R de JR da, Figueiredo CR de, Fernandes MC. Politica nacional de praticas integrativas e complementares em saude: discurso dos enfermeiros da atencao basica [Internet]. RECOM. 2019 [acesso 20 abr. 2023];9:e3265. DOI: DOI: https://doi.org/10.19175/recom.v9i0.3265

DP Soares AM Coelho LEA da Silva JR da Silva R de CR de Figueiredo MC Fernandes Politica nacional de praticas integrativas e complementares em saude: discurso dos enfermeiros da atencao basicaRECOM201920 abr. 20239e3265 DOI: https://doi.org/10.19175/recom.v9i0.3265

[6] Article derived from the master’s thesis in nursing entitled “Propriedades terapéuticas da Anredera cordifolia nas doenças crônicas não transmissíveis: Revisão de escopo” [Therapeutic properties of Anredera cordifolia in non transmissible chronic diseases: A scope review], defended at Universidade Federal de Santa Maria, Brazil. Available at: http://repositorio.ufsm.br/handle/1/28051

[7] Artículo derivado de la tesis de maestría profesional en enfermería "Propriedades terapêuticas da Anredera cordifolia nas doenças crônicas não transmissíveis" ("Propiedades terapéuticas de la Anredera cordifolia en las enfermedades crónicas no transmisibles"), presentada en la Universidade Federal de Santa Maria, Brasil. Disponible en: http://repositorio.ufsm.br/handle/1/28051

[8] Artigo derivado da dissertação de mestrado acadêmico em enfermagem intitulada "Propriedades terapêuticas da Anredera cordifolia nas doenças crônicas não transmissíveis", defendida na Universidade Federal de Santa Maria, Brasil. Disponível em: http://repositorio.ufsm.br/handle/1/28051

[9] Trombini FS, Heisler EV, Corcini LMCS, Badke MR, Schimith MD. Potential therapeutic use of Anredera cordifolia in chronic non-communicable diseases: A scoping review. Aquichan. 2024;24(2):e2428. DOI: https://doi.org/10.5294/aqui.2024.24.2.8

[10] Promoting health, well-being, and quality of life

[11]The lack of a scientific basis regarding medicinal plants constitutes a significant barrier to safe healthcare. Therefore, it is imperative for health professionals to gain access to scientific knowledge concerning these plants and to be encouraged to conduct new research into their properties, effects, and safe usage. Medicinal plants are considered a potential therapeutic resource for inclusion in healthcare practices, and research on this topic can support their safe utilization. In this context, this study aims to contribute to further research into the properties of Anredera cordifolia.

**Potential Therapeutic use of Anredera cordifolia in Chronic Non-Communicable Diseases: A Scoping Review***

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