Introduction
Life takes place in a context of fast and continuous change in various aspects. As
a result, there is an increased demand for ways of (re) adapting, which results in
depressive pathologies due to the psychological suffering caused 1,2. According to estimates from the 2021 Global Burden of Disease study, among the global
population, more than one billion people were living with a mental disorder, of which
357 million were living with depression 3.
Depression presents concerning data in Brazil, according to a Brazilian study that
shows an increase in its incidence. The Surveillance of Risk and Protective Factors
for Chronic Diseases Telephone Survey (Vigitel), conducted in 2021, found that an
average of 11.3 % of Brazilians reported having received a medical diagnosis of the
disease, with a higher incidence among women (14.7 %) compared to men (7.3 %) 4.
In addition, this illness is a public health problem with a significant prevalence
in various populations. Recent data indicates the odds of receiving a medical diagnosis
of depression are higher among urban residents, women, people aged from 40 to 69,
white individuals, those with lower levels of education, separated or divorced, current
smokers, "heavy" screen users, as well as individuals who have reported medical diagnoses
of physical and mental disorders 5-7.
The clinical picture of this illness requires complex therapeutic management. It can
be achieved through pharmacological therapies and a combination of other non-pharmacological
therapies, such as integrative and complementary health practices (ICHP). Health interventions
must consider individuals in their multiple dimensions, with their choices, values,
desires, anxieties, and fears. Thus, it is possible to promote the recovery and maintenance
of patients' I health throughout the treatment 8.
To implement integrative and complementary health measures within the Brazilian Unified
Health System, the National Policy for Integrative and Complementary Practices was
published by the Minister's Office-Ministry of Health Ordinance 971 on May 3, 2006
9. These include traditional Chinese medicine/acupuncture, homeopathy, medicinal plants
and phytotherapy, meditation, music therapy, reiki, yoga, and aromatherapy, among
others 10.
Yoga, which is covered by ICHP, is a multidimensional system of health and well-being
that interconnects mind and body during its performance; it is a practice that articulates
physical postures and movements, aligned with breathing exercises and relaxation.
It is worth mentioning that during the exercise, meditation can be associated with
a way of perceiving feelings and sensations 11.
In addition, it is a practice that offers health benefits, such as physical, philosophical,
and social contributions. Some of these include encouraging healthier diets and body
awareness, developing contemplative capacity, and promoting a peaceful culture and
healthy lifestyles. Yoga philosophy has a clear relationship with health promotion,
offering forms of care for chronic conditions related to physical and psychological
factors 12.
Despite the promising results reported in previous reviews, it is still necessary
to conduct a broader review that addresses the variability of yoga practices. In light
of this and given the impact on the quality of life of people with depression, as
well as the viability of ICHP as a complementary treatment, the present study aims
to analyze the scientific evidence available in databases on the efficacy of yoga
in reducing depressive symptoms.
Materials and Methods
The present study consists of a systematic literature review. The review was conducted
in line with the Joanna Briggs Institute (JBI) methodology for systematic reviews
on efficacy 13. The protocol for this systematic review was approved via Prospero under registration
CRD42023448158.
According to the JBI, eight stages must be followed to conduct a systematic literature
review of any type of evidence: I. development of the research question; II. definition
of inclusion and exclusion criteria; III. literature search; IV study selection; V.
assessment of methodological quality; VI. data extraction; VII analysis and synthesis;
VIII presentation and interpretation of the results 14.
The design of the research question is essential when starting a systematic review,
as it defines the focus of the study. In this case, it was accomplished through the
"PICO" strategy: P - population; I - intervention; C - comparison; O - outcomes 15, where "P" stands for people with depression, "I" for yoga, "C" for people who have
not been submitted to yoga, and "O" for improvement/reduction of depressive symptoms.
Thus, the following question was devised: What is the efficacy of yoga in reducing
depressive symptoms?
Primary studies with a randomized clinical trial (RCT) design were included, in which
any variation of yoga was adopted as a practice for reducing depressive symptoms,
of both sexes, of any age, with no defined time frame, published in any language.
Literature reviews, editorials, case studies, letters to the editor, dissertations,
theses, incomplete studies, gray literature, and studies that failed to answer the
research question were excluded.
The following databases were used to conduct the bibliographic search: Medical Literature
Analysis and Retrieval System Online/ PubMed (Medline); Web Of Science (WOS); Latin
American and Caribbean Health Sciences Literature (Lilacs), via the Virtual Health
Library (VHL); Nursing Database (BDEnf), via the VHL; Spanish Bibliographic Index
of Health Sciences (Ibecs), also via the VHL; American Psychological Association (APA);
PsycINFO and Cumulative Index to Nursing and Allied Health Literature (Cinahl)/EBSCO.
Along with the databases mentioned above, a secondary search was conducted on Google
Scholar. The reference lists of all the evidence sources included were also examined
manually to find relevant studies that could be added.
To integrate the search strategy for the studies, controlled descriptors (indexed
in the respective databases) were selected using the Descritores em Ciências da Saúde (DeCS): depressão, depression, depresión, transtorno depressivo, depressive disorder, trastorno depresivo, yoga; from the Medical Subject Headings (MeSH terms): depression, depressive disorder,
yoga, treatment outcome; from the APA thesaurus: depression, major depression, yoga,
treatment outcome; from Cinahl Subjects: depression, yoga, treatment outcome; and
from alternative terms: sintomas depressivos, depressive symptoms.
With the aim of broadening the search strategy, controlled and non-controlled descriptors
were combined using the Boolean operators AND and OR. Table 1 shows the final search strategy used in the various databases.
Table 1
Search Strategy Used in the Databases Searched
|
Database
|
Search Strategy
|
|
Medline/PubMed
|
(((Depression) OR ("Depressive disorder")) AND (Yoga)) AND (Treatment Outcome)
|
|
Web of Science
|
((((ALL=(Depression)) OR ALL=(Depressive Disorder)) OR ALL=(Depressive Symptom)) AND
(ALL=(Yoga))) AND (ALL=(Treatment Outcome))
|
|
BVS (Lilacs, BDEnf, and Ibecs)
|
((Depressão) OR (Depression) OR (Depresión) OR (Transtorno Depressivo) OR (Depressive
Disorder) OR (Trastorno Depresivo) OR (Sintomas Depressivos)) AND (Yoga)
|
|
PsycINFO
|
Any Field: Depression OR Any Field: Major Depression AND Any Field: Yoga AND Any Field: Treatment Outcomes
|
|
Cinahl/Ebsco
|
Depression AND Yoga AND Treatment Outcome
|
After conducting the literature search, the articles were exported to the bibliographic
software EndNote (https://www.myendnoteweb.com/) to exclude duplicates. Subsequently, the studies were exported to the Rayyan selection
platform (https://www.rayyan.ai/) to select and identify the studies.
Two reviewers participated independently in the process during August 2024, and any
disagreements were settled through discussion. The research results were presented
in line with the guidelines of the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses - Prisma flowchart 16.
After the selection of eligible articles, the methodological quality of the studies
was assessed. The Jadad Scale was used 17, which is a questionnaire consisting of five questions. The score ranges from zero
to five, where studies with a score lower than three are considered to be low quality
and studies with a score equal to or above three are classified as high quality.
The level of bias was assessed using the Cochrane Collaboration's Risk of Bias 2 (RoB2)
tool. This tool was developed to assess RCTs and covers five domains: Bias in the
randomization process; bias due to deviations from the intended interventions; bias
due to missing outcome data; bias in the measurement of outcomes; and bias in the
selection of reported results. Assessment with RoB2 consists of answering specific
questions within each domain 18.
The data were extracted and compiled by two independent reviewers, using an adapted
instrument based on a previous study 19, in the Microsoft® Word program. The following information was extracted: Authors, publication year,
sample, intervention, control group, and main results.
Finally, a descriptive analysis and synthesis of the articles selected to comprise
this review were performed, which were discussed in the light of the existing literature.
Results
The database search yielded 1138 studies, and no additional studies were included
after searching Google Scholar and the reference lists of the included evidence. After
removing duplicates (203), 935 eligible studies remained for analysis of their titles
and abstracts, at which point 889 were excluded for potentially not fitting the eligibility
criteria.
Afterward, 46 records were submitted for critical evaluation, which led to the exclusion
of 36 of them. Of those excluded, 14 were not RCTs and 22 failed to answer the research
question. As a result, only 10 records met all the inclusion criteria and were selected
for the data extraction, detailed reading, and qualitative synthesis stage. The flow
of the search process is shown in Figure 1, following the guidelines of the Prisma flowchart 16.
Figure 1
Study Selection Flowchart, in line with the Prisma guidelines
Source: Prepared by the authors.
Table 2 presents a summary of the main properties of the studies included in the qualitative
analysis. The publication years of the studies ranged from 2015 to 2023. In terms
of the participants' composition, five studies included only women, mostly due to
the associated condition being inherent to the female sex, while the other half included
both sexes. The mean number of participants in the study samples was 79, with a minimum
of 20 and a maximum of 138.
Table 2
Description of the articles included
|
Authors (Publication Year)
|
Sample
|
Intervention
|
Control group
|
Main Results
|
|
Uebelacker et al. (2023) 20
|
42 adolescents with severe symptoms of depression
|
Yoga
|
The yoga intervention included an initial personal guidance meeting between the yoga
teacher and the participant and then a weekly 45-minute class for 12 weeks.
|
The study demonstrated the acceptability and viability of yoga as an intervention
for adolescents with symptoms of depression.
|
|
Liu et al. (2022) 21
|
136 women diagnosed with breast cancer
|
Mindfulness yoga
|
90 minutes of weekly practice over eight weeks: the first stage consists of mindfulness
meditation (20 minutes); the second stage of mindfulness yoga postures followed by
mindfulness breathing guidance (50 minutes); the third stage of mindfulness yoga body
scanning (10 minutes); and the fourth stage of sensory summarization and questions
and answers (10 minutes).
|
The group that received mindfulness yoga combined with conventional care had better
results than the control group, especially in terms of anxiety, depression, and health-related
quality of life.
|
|
Bieber et al. (2021) 22
|
83 participants with major depressive disorder
|
Yoga
|
The yoga classes lasted 90 minutes each and were held three times a week for 12 weeks
in groups of 10 to 12 patients.
|
In the yoga group, there was a significant improvement in the remission rates of depression
severity compared to the control group.
|
|
Huberty et al. (2020) 23
|
90 women who experienced stillbirths
|
Hatha yoga
|
The intervention groups (low-dose intervention = 60 minutes/week of yoga; moderate-dose
intervention = 150 minutes/week of yoga) were guided by a 12-week online yoga prescription
developed by the research team.
|
After the intervention, a significant reduction was found in the symptoms of post-traumatic
stress disorder and depression, as well as an improvement in self-rated health.
|
|
Sharma et al. (2020) 24
|
66 patients with heart disease
|
Yoga
|
A one-hour supervised yoga module consisting of asanas (physical postures), pranayama
(breathing techniques), and relaxation techniques performed three times a week for
12 weeks.
|
The addition of yoga to cardiac rehabilitation reduces depression and anxiety, improving
patients' quality of life.
|
|
Kwok et al. (2019) 25
|
138 adults diagnosed with Parkinson's disease (PD)
|
Mindfulness yoga
|
The group received a weekly 90-minute session of mindfulness yoga for PD for eight
weeks.
|
Mindfulness yoga is effective in improving motor dysfunction and mobility in patients
with mild to moderate PD. It also offers additional benefits, such as reducing anxiety
and depressive symptoms, and increasing spiritual well-being.
|
|
Kumar et al. (2019) 26
|
80 patients with major depressive disorder
|
Yoga
|
20 supervised yoga sessions, comprising five sessions a week, each lasting 45 minutes.
|
The group that practiced yoga showed a significant reduction in depression scores
and a notable clinical improvement compared to the control group.
|
|
Chu et al. (2017) 27
|
26 sedentary women with a score ≥ 14 on the Beck Depression Inventory-II
|
Yoga
|
The yoga module lasted 12 weeks, held twice a week for 60 minutes per session, and
consisted of breathing exercises, practicing yoga postures, and supine meditation/relaxation.
|
The intervention demonstrated efficacy by increasing the activity of the parasympathetic
nervous system and reducing symptoms of depression and perceived stress in women with
significant depressive symptoms.
|
|
Buttner et al. (2015) 28
|
57 women with postpartum depression
|
Gentle vinyasa flow yoga
|
The intervention consisted of a total of 16 one-hour yoga classes held over eight
weeks.
|
The yoga group showed significantly greater improvement in depression, anxiety, and
health-related quality of life compared to the control group, with moderate to large
effects.
|
|
Yagli, Ulger (2015) 29
|
20 female breast cancer patients
|
Yoga
|
Each session was held for one hour a week for eight weeks and included warm-up and
breathing exercises (15 minutes), asanas (15 minutes), relaxation and meditation in
the supine position (30 minutes).
|
Statistically significant differences were found in depression, pain, fatigue, and
sleep quality between the groups, both before and after the intervention.
|
Analysis of the table reveals several significant trends. First, the efficacy of yoga
in diverse populations can be noted, ranging from adolescents with symptoms of depression
20, breast cancer patients 21,29, women who have suffered stillbirths 23, heart disease patients 24, adults with PD 25, to women with postpartum depression 29. In addition, beyond the studies that used traditional yoga as an intervention, other
studies covered various forms of yoga, such as hatha yoga 23, mindfulness yoga 21,25 and gentle vinyasa flow yoga 28. In all the studies, the groups that practiced yoga demonstrated acceptability, viability,
and improved results.
When analyzing the methodological quality of the RCTs, it can be noted that most of
them have flaws in the study's blinding, which may be directly related to the nature
of the intervention applied, as is the case with yoga. Using the Jadad Scale as an
evaluation criterion, eight studies were considered to be of high quality, while two
were classified as low quality. These two low-quality studies were deficient in adequate
blinding and in reporting losses and exclusions (Table 3).
Table 3
Methodological Quality Analysis with the Jadad Scale
|
|
Was the study described as randomized?
|
Was the randomization method adequate?
|
Was the study described as double-blind?
|
Was the blinding method adequate?
|
Were losses and exclusions described?
|
Total score
|
|
Studies
|
Questions
|
|
Uebelacker et al., 2023 20
|
1
|
1
|
0
|
0
|
1
|
3
|
|
Liu et al., 2022 21
|
1
|
1
|
1
|
-1
|
1
|
3
|
|
Bieber et al., 2021 22
|
1
|
1
|
1
|
-1
|
1
|
3
|
|
Huberty et al., 2020 23
|
1
|
1
|
0
|
0
|
1
|
3
|
|
Sharma et al., 2020 24
|
1
|
1
|
0
|
0
|
1
|
3
|
|
Kwok et al., 2019 25
|
1
|
1
|
1
|
1
|
1
|
5
|
|
Kumar et al., 2019 26
|
1
|
1
|
0
|
0
|
0
|
2
|
|
Chu et al., 2017 27
|
1
|
1
|
0
|
0
|
1
|
3
|
|
Buttner et al., 2015 28
|
1
|
1
|
0
|
0
|
1
|
3
|
|
Yagli, Ulger, 2015 29
|
1
|
1
|
0
|
0
|
0
|
2
|
Regarding the risk of bias, which was assessed using the RoB2 tool, three studies were classified as having a low risk of bias, three as having
a high risk of bias, and four presented some suspicions (Table 4). It is worth noting that, in some cases, the specific properties of the interventions
used hindered the blinding of the professionals providing the treatment and there
were withdrawals from therapy during the course of the studies, which may have influenced
the assessment of the risk of bias in these clinical trials.
Table 4
Risk of Bias Assessment of Randomized Clinical Trials in Each Domain of the Cochrane
Collaboration's RoB 2 tool
|
|
Randomization process
|
Deviations from intended interventions
|
Lack of outcome data
|
Outcome measurement
|
Selection of the reported result
|
Global risk of bias
|
|
Studies
|
Risk of bias domain
|
|
Uebelacker et al., 2023 20
|
|
|
Liu et al., 2022 21
|
|
Bieber et al., 2021 22
|
|
Huberty et al., 2020 23
|
|
Sharma et al., 2020 24
|
|
Kwok et al., 2019 25
|
|
Kumar et al., 2019 26
|
|
Chu et al., 2017 27
|
|
Buttner et al., 2015 28
|
|
Yagli, Ulger, 2015 29
|
The yoga intervention has a particularity that makes it difficult to conceal it from
participants who are receiving the treatment. Its active practice and patients' participation
in the exercise routine also make the blinding process difficult. In addition, differences
in expectations between participants can emerge, as each may have different opinions
about the benefits of yoga compared to other interventions, which can influence their
perceptions and responses to treatments.
Discussion
This study provides a significant contribution to the advancement of knowledge in
the field of complementary health therapies. Analyzing various studies, a consistently
positive effect of yoga in reducing depressive symptoms was found in different populations
and settings. These results highlight its effectiveness as a complementary therapeutic
approach in the management of depression.
Yoga practice, which combines breathing, physical postures and meditation, has been
widely recognized and used for decades as an effective way to reduce stress and promote
general health. Studies and case reports have shown that yoga can have positive effects
on reducing symptoms of post-traumatic stress disorder (PTSD), anxiety, and depression
in various populations 30,31. Yoga has also been shown to be a valuable complementary approach to reducing stress
during pregnancy and aiding in the prevention and treatment of postpartum depression
28,32,33.
Although there is still uncertainty surrounding the exact mechanism by which yoga
reduces the symptoms of PTSD, anxiety, and depression, it is possible to attribute
these benefits, at least in part, to improvements in mindfulness, emotional regulation,
self-compassion, and sleep quality. By cultivating mindfulness, yoga offers a way
of directing attention and increasing awareness of the mind and body. This improvement
in mindfulness can increase acceptance of one's emotions, improve emotional regulation,
and reduce avoidance. Additionally, yoga can help raise awareness of negative beliefs
about oneself, such as self-criticism, and promote the practice of self-compassion
34,35.
Joint yoga therapy has been widely studied as a complementary approach to the treatment
of depressive disorders. A clinical trial with § patients diagnosed with major depressive
disorder found participants in the yoga therapy group showed a significantly greater
reduction in levels of depression. Furthermore, they showed notable clinical improvements
when compared to the control group. These results suggest that this practice can have
a relevant role as joint therapy in the treatment of depressive disorders, contributing
to a significant improvement in symptoms and, consequently, in patients' quality of
life 26.
Another study 22 conducted with individuals diagnosed with major depressive disorder showed that yoga
practice can be an effective intervention. Moreover, its regular practice demonstrated
significant improvements in symptoms of depression, with participants in the yoga
group showing a more pronounced reduction in the severity of depression compared to
the control group. A crucial point raised by the researchers was the need for constant
motivation and a certain level of energy and skills in daily activities, which are
often limited in the presence of depression.
Currently, the incidence of depression is alarming, affecting more than 300 million
people worldwide. It is worth noting that from adolescence onwards, women are twice
as likely to develop depression than men. The disease also tends to emerge in a more
intense form in women 36-38. Given this scenario, it is extremely important for women to seek effective strategies
to deal with depressive symptoms and improve their psychological well-being to achieve
and maintain a satisfactory quality of life.
Online yoga practice has proven to be a promising tool for reducing PTSD and depression
in women who have undergone the devastating experience of maternal death. By practicing
yoga in this modality, women have the flexibility to adapt classes to their J pace
and individual needs, allowing for a personalized approach to healing and the trauma
recovery process. Online yoga thus emerges as a valuable therapeutic tool to assist
the healing process and rebuild emotional balance 23.
In turn, the effect of mindfulness yoga has been studied in women with early breast
cancer who also suffer from depression 21. Studies have revealed a strong correlation between the presence of depression and
decreased quality of life in patients with this diagnosis 39-42. Mindfulness yoga combines the benefits of yoga, which includes physical postures,
breathing, and meditation, with the practice of mindfulness, which focuses on full
awareness of the present moment 21,43.
This integrated approach using mindfulness yoga has been shown to be a complementary
strategy to conventional treatment for depression in patients with early breast cancer,
providing a holistic care perspective and strengthening mental health during the healing
process 21. Isolated yoga practice has also been shown to be valuable in reducing depression,
pain, and fatigue, as well as helping women with breast cancer to perform their daily
and routine activities 29,44,45.
Added to this, a study 27 shows that regular yoga practice has been shown to be beneficial for women in terms
of improving heart rate variability and relieving depressive symptoms. The study indicates
that yoga can be recommended as an effective strategy for addressing depressive symptoms
and stress, as well as improving heart rate variability, and this evidence is supported
by another study 46. Through regular practice, women can reduce their risk of developing cardiovascular
disease, promoting better cardiovascular health and improving their quality of life
in general 27,46.
Yoga practice has also been shown to be effective in the treatment of women with postpartum
depression. A study 28 showed that women who participated in a yoga group experienced significant improvements
in several measurements related to mental health, in comparison to the control group.
The benefits were seen in terms of reduced depression and anxiety, as well as an increase
in health-related quality of life. These improvements happened at a notably faster
rate than in the control group, indicating that yoga can be an effective and accessible
therapeutic approach for women facing emotional challenges in the postpartum period
28.
Further regarding mindfulness yoga practice, when compared to stretching exercises
and resistance training, statistically and clinically significant effects have been
found in reducing depression symptoms in people with PD. When practicing yoga, individuals
with PD are encouraged to focus on body movements, breathing, and internal sensations,
fostering a deeper awareness of the body and of themselves. The regular practice of
mindfulness yoga has been associated with a significant reduction in symptoms of depression,
improved motor dysfunction and mobility, providing well-being 25.
Depression emerges as a significant source of psychological challenges faced by middle-aged
men (aged 40 to 60). This condition triggers debilitating symptoms, including reduced
mood, loss of motivation and interest, feelings of guilt or incompetence, disturbed
sleep and appetite, as well as a sharp drop in energy and ability to concentrate.
These elements have an adverse impact on daily activities and social interactions,
leading to a noticeable deterioration in quality of life 47. However, a study shows that mindfulness yoga is an effective method for helping
this group to reduce symptoms of depression, increase self-esteem, and improve their
quality of life 48.
Yoga has been shown to be a viable and highly acceptable option for treating depression
in adolescents. They often face emotional challenges and stress due to physical changes
alongside academic and social pressure. The regular practice of this activity helps
adolescents to develop emotional self-regulation skills, reducing depressive symptoms,
and providing improvement in anxiety and sleep disorders. With its positive effects
and accessibility, yoga is accepted as a complementary therapeutic approach to help
adolescents deal with depression 20,49.
After suffering an acute myocardial infarction, patients face negative consequences
resulting from the secondary manifestations of atherosclerosis, such as anxiety and
depression. These symptoms ° have a significant impact on the prognosis of coronary
artery disease 50. Yoga practice, along with meditation and breathing exercises, contributes to a decrease
in sympathetic activity, which results in a reduction in ventricular filling pressure.
A clinical trial conducted with cardiac patients found that yoga has a valuable role
in reducing levels of depression in these individuals, resulting in a significant
improvement in their quality of life 24.
This review provides several important contributions to both research and clinical
practice, as it has shown the effectiveness of yoga in reducing depressive symptoms.
It also provides valuable insights into the efficacy of yoga in various populations
and settings.
However, it is worth highlighting a significant limitation. There was notable heterogeneity
in terms of the types of yoga used, the duration of the interventions, the follow-up
length, and the reporting of concurrent use of medication therapy. This diversity
of approaches may limit the generalizability of the results found and warrants caution
when interpreting the findings of this review.
Conclusion
Based on the analysis of the included studies, it is possible to conclude that yoga
shows efficacy in reducing depressive symptoms in various populations. The studies
analyzed, which ranged from publications from 2015 to 2023, included participants
with various conditions, such as adolescents with symptoms of depression, breast cancer
patients, women who have suffered stillbirths, heart disease patients, adults with
PD, and women with postpartum depression. In all cases, yoga practice was associated
with a significant improvement in depressive symptoms and was considered acceptable
and viable.
Therefore, yoga is highlighted as an accessible, effective, and acceptable therapeutic
tool, having a relevant role in the treatment of depression and the promotion of emotional
and physical well-being in various populations. Its wide-ranging benefits suggest
that this ancient practice could be incorporated as an integral part of holistic therapeutic
approaches, providing an additional option for improving the quality of life of people
affected by depression and related conditions.
