Efectividad del jengibre en el tratamiento de la diabetes mellitus tipo 2: estudio piloto del tipo ensayo clínico aleatorizado

Autores/as

DOI:

https://doi.org/10.5294/aqui.2021.21.1.5

Palabras clave:

Diabetes mellitus tipo 2, jengibre, ensayo clínico, atención primaria de salud, terapias complementarias

Resumen

Objetivo: analizar la efectividad del jengibre en la reducción de los niveles glicémicos, lipídicos y antropométricos de personas con diabetes mellitus tipo 2.

Materiales y método: estudio piloto, del tipo ensayo clínico aleatorizado, doble ciego, llevado a cabo entre octubre de 2017 y enero de 2018. Los criterios de inclusión fueron los siguientes: personas con diabetes tipo 2, de 18 a 80 años de edad, en uso de antidiabéticos orales y con valores de hemoglobina glicada entre 7 % y 10 %. Los participantes fueron aleatorizados y asignados en dos grupos distintos. En el grupo experimental, los participantes usaron 1,2 g de jengibre y, en el de control, 1,2 g de placebo. El resultado primario fue la reducción de la glicemia. La reducción de los niveles lipídicos y antropométricos fue el resultado secundario. La intervención duró cuatro semanas.

Resultados: 21 participantes formaron parte del estudio. El uso de 1,2 g de jengibre evidenció perceptibles reducciones de los niveles antropométricos y lipídicos en 30 días de seguimiento, pero no se mostró suficiente para reducir los niveles glicémicos.

Conclusiones: en el estudio se demostró que cápsulas de jengibre, en dosis de 1,2 g por día, pueden ayudar a reducir medidas antropométricas y niveles lipídicos en la población del estudio, sin embargo, sin efecto en los niveles glicémicos.

Biografía del autor/a

Gerdane Celene Nunes Carvalho, Universidade Estadual do Piauí

Doutora em Enfermagem. Universidade Estadual do Piauí, Departamento de Enfermagem, Picos, PI, Brasil.

Jose Claudio Garcia Lira Neto, Universidade Federal do Piauí

Doutor em Enfermagem. Departamento de Enfermagem, Universidade Federal do Piauí. Floriano, PI, Brasil.

Lívio César Cunha Nunes, Universidade Federal do Piauí

Doutor em Farmacologia. Universidade Federal do Piauí, Departamento de Farmácia, Teresina, PI, Brasil.

Ana Maria Parente Garcia Alencar, Universidade Regional do Cariri

Doutora em Enfermagem. Universidade Regional do Cariri, Departamento de Enfermagem, Crato, CE, Brasil.

Regina Lúcia Lino Marques, Centro de Pesquisa em Diabetes e Doenças Endócrino Metabólicas

Enfermeira. Departamento de Enfermagem. Centro de Pesquisa em Diabetes e Doenças Endócrino Metabólicas, Fortaleza, CE, Brasil.

Marta Maria Coelho Damasceno, Universidade Federal do Ceará

Doutora em Enfermagem. Universidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Departamento de Enfermagem, Fortaleza, CE, Brasil. Bolsista de Produtividade em Pesquisa do CNPq – Nível 1D.

Citas

Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet Diabetes Endocrinol [internet]. 2017; 389:2239-51. DOI: http://dx.doi.org/10.1016/S0140-6736(17)30058-2

Khunti K, Nikolajsen A, Thorsted BL, Andersen M, Davies MJ, Paul SK. Clinical inertia in intensifying therapy among people with type 2 diabetes treated with basal insulin. Diabetes Obes Metab [internet]. 2016; 8:401-9. DOI: https://doi.org/10.1111/dom.12626

Zhu J, Chen H, Song Z, Wang X, Sun Z. Effects of ginger (Zingiber officinale roscoe) on Diabetes Mellitus Type 2 and components of the metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med [internet]. 2018; 2018:5692962. DOI: https://doi.org/10.1155/2018/5692962

Huang F-Y, Deng T, Meng L-X, Ma X-L. Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Medicine (Baltimore) [internet]. 2019; 98(13):e15054. DOI: https://doi.org/10.1097/MD.0000000000015054

Wang J, Ke W, Bao R, Hu X, Chen F. Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: A review. Ann N Y Acad Sci [internet]. 2017; 1398(1):83-98. DOI: https://doi.org/10.1111/nyas.13375

Honarvar NM, Zarezadeh M, Khorshidi M, Arzati MM, Yekaninejad MS, Abdollahi M et al. The effect of an oral ginger supplementation on NF-kB concentration in peripheral blood mononuclear cells and anthropomorphic data of patients with type 2 diabetes: A randomized double-blind, placebo-controlled clinical trial. Complement Ther Med [internet]. 2019; 42:7-11. DOI: https://doi.org/10.1016/j.ctim.2018.10.019

Kiyama R. Nutritional implications of ginger: Chemistry, biological activities and signaling pathways. J Nutr Biochem [internet] 2020; 86:108486. DOI: https://doi.org/10.1016/j.jnutbio.2020.108486

Wang Y, Yu H, Zhang X, Feng Q, Guo X, Li S et al. Evaluation of daily ginger consumption for the prevention of chronic diseases in adults: A cross-sectional study. Nutrition [internet]. 2017; 36:79-84. DOI: https://doi.org/10.1016/j.nut.2016.05.009

Rahimlou M, Yari Z, Rayyani E, Keshavarz SA, Hosseini S, Morshedzadeh N et al. Effects of ginger supplementation on anthropometric, glycemic and metabolic parameters in subjects with metabolic syndrome: A randomized, double-blind, placebo-controlled study. J Diabetes Metab Disord [internet] 2019; 18(1):119-25. DOI: https://doi.org/10.1007/s40200-019-00397-z

Lipschitz DA. Screening for Nutritional Status in the Elderly. Prim Care [internet]. 1994; 21(1):55-67. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8197257

Vasques AC, Rosado L, Rosado G, Ribeiro RC, Franceschini S, Geloneze B. Anthropometric indicators of insulin resistance. Arq Bras Cardiol [internet]. 2010; 95(1):14-23. Available from: http://www.scielo.br/pdf/abc/v95n1/en_a25v95n1.pdf

Segheto W, Hallal PC, Marins JCB, da Silva DCG, Coelho FA, Ribeiro AQ et al. Factors associated with body adiposity index (BAI) in adults: Population-based study. Cien Saude Colet [internet]. 2018; 23(3):773-83. DOI: http://doi.org/10.1590/1413-81232018233.11172016

Setiati S, Istanti R, Andayani R, Kuswardhani RA, Aryana IG, Putu ID, Apandi M, Inchwani J, Soewoto S, Dinda R, Mustika S. Cut-off of Anthropometry measurement and nutritional status among elderly outpatient in Indonesia: Multi-centre study. Acta Med Indones [internet]. 2010; 42(4):224-30. Available from: http://www.inaactamedica.org/archives/2010/21063044.pdf

Malachias MVB, Souza WKSB, Plavnik FL, Rodrigues CIS, Brandão AA, Neves MFT et al. VII Brazilian guidelines for hypertension. Arq Bras Cardiol [internet]. 2016; 107(3):1-83. Available from: http://publicacoes.cardiol.br/2014/diretrizes/2016/05_HIPERTENSAO_ARTERIAL.pdf

Brazilian Diabetes Society. Guidelines from the Brazilian Diabetes Society: 2017-2018 [internet]. 2017. Available from: https://www.diabetes.org.br/profissionais/images/2017/diretrizes/diretrizes-sbd-2017-2018.pdf

Faludi AA, Izar MCO, Saraiva JFK, Chacra APM, Bianco HT, Afiune Neto A et al. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose — 2017. Arq Bras Cardiol [internet]. 2017; 109(2 suppl 1):1-76. Disponível em: http://publicacoes.cardiol.br/2014/diretrizes/2017/02_DIRETRIZ_DE_DISLIPIDEMIAS.pdf

Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Nutr [internet]. 2013; 64(6):682-6. DOI: http://doi.org/10.3109/09637486.2013.775223

Azimi P, Ghiasvand R, Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycaemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes patients. Rev Diabet Stud [internet]. 2014; 11(3-4):258-66. DOI: http://doi.org/10.1900/RDS.2014.11.258

Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycaemic indices in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Complement Ther Med. [internet]. 2014; 22(1):9-16. DOI: http://doi.org/10.1016/j.ctim.2013.12.017

Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiber officinale) on glycaemic markers in patients with type 2 diabetes. J Complement Integr Med [internet]. 2015; 12(2):165-70. DOI: http://doi.org/10.1515/jcim-2014-0021

Atashak S, Peeri M, Azarbayjani MA, Stannard SR, Haghighi MM. Obesity-related cardiovascular risk factors after long-term resistance training and ginger supplementation. J Sports Sci Med [internet]. 2011; 10(4):685-91. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761505/pdf/jssm-10-685.pdf

Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: A brief review. Evid Based Complement Alternat Med. [internet]. 2012; 2012:516870. DOI: http://doi.org./10.1155/2012/516870

Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr [Internet]. 2006; 96(4):660-6. DOI: http://doi.org/10.1079/BJN20061849

Ozougwu JC, Eyo JE. Evaluation of the activity of Zingiber officinale (ginger) aqueous extracts on alloxan-induced diabetic rats. Pharmacologyonline [internet]. 2011; 1:258-69. Available from: https://pharmacologyonline.silae.it/files/archives/2011/vol1/026.ozougwu.pdf

Kazeem MI, Akanji MA, Yakubu MT, Ashafa AOT. Protective effect of free and bound polyphenol extracts from ginger (Zingiber officinale Roscoe) on the hepatic antioxidant and some carbohydrate metabolizing enzymes of streptozotocin-induced diabetic rats. Evid Based Complement Alternat Med [internet]. 2013; 2013:935486. DOI: http://doi.org/10.1155/2013/935486

Oludoyin AP, Adegoke SR. Efficacy of ginger (Zingiber officinale Roscoe) extracts in lowering blood glucose in normal and high fat diet-induced diabetic rats. Am J Food Nutr [internet]. 2014;2(4):55-8. Available from: http://pubs.sciepub.com/ajfn/2/4/1/index.html

Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini AF, Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr [internet]. 2014; 65(4):515-20. DOI: http://doi.org/10.3109/09637486.2014.880671

Arzati MM, Honarvar NM, Saedisomeolia A, Anvari S, Effatpanah M, Arzati RM et al. The effects of ginger on fasting blood sugar, hemoglobin a1c, and lipid profiles in patients with type 2 diabetes. Int J Endocrinol Metab [internet]. 2017; 15(4):e57972. DOI: http://doi.org/10.5812/ijem.57927

Miranda Neto MV, Rewa T, Leonello VM, Oliveira MAC. Advanced practice nursing: A possibility for Primary Health Care?. Rev Bras Enferm [internet]. 2018; 71(supl 1):716-21. [Issue Edition: Contributions and challenges of practices in collective health nursing]. DOI: http://dx.doi.org/10.1590/0034-7167-2017-0672

Cassiani SHB, Lira Neto JCG. Nursing perspectives and the “Nursing Now” campaign. Rev Bras Enferm [internet]. 2018; 71(5):2351-2. DOI: http://dx.doi.org/10.1590/0034-7167.2018710501

Publicado

2021-04-08

Cómo citar

Nunes Carvalho, G. C., Garcia Lira Neto, J. C., César Cunha Nunes, L., Parente Garcia Alencar, A. M., Lúcia Lino Marques, R., & Coelho Damasceno, M. M. (2021). Efectividad del jengibre en el tratamiento de la diabetes mellitus tipo 2: estudio piloto del tipo ensayo clínico aleatorizado. Aquichan, 21(1), e2115. https://doi.org/10.5294/aqui.2021.21.1.5

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