Dor devido à polineuropatia simétrica distal em diabetes mellitus
DOI:
https://doi.org/10.5294/aqui.2021.21.3.7Palavras-chave:
Neuropatias diabéticas, dor crônica, diabetes mellitus, complicações, fisioterapia, enfermagemResumo
Objetivo: avaliar a dor neuropática (DN), sua intensidade e suas complicações em pessoas com diabetes mellitus tipo 2 (DM2) numa cidade do leste de São Paulo, Brasil.
Método: estudo transversal realizado com 96 indivíduos com DM2 atendidos em unidades básicas de saúde em São João da Boa Vista, São Paulo. Foram utilizados os seguintes instrumentos para rastrear a DN: o instrumento para detectar a neuropatia de Michigan, a avaliação de sinais e sintomas neuropáticos de Leeds, o questionário de Douleur Neuropathique 4 e a escala breve da dor. Os dados foram analisados por meio de estatística descritiva e inferencial, com um nível de significância de 5 %.
Resultados: das 96 pessoas com DM2 durante mais de cinco anos, 22,9 % sentiam dor. A DN esteve relacionada com níveis altos de glicose em sangue em jejum (média = 214 ± 65,58 mg/dl; p = 0,0002), hemoglobina glicosilada (média = 8,8 ± 0,11 %; p < 0,001), ausência de dieta (p = 0,0066), obesidade (p = 0,023) e hipertensão arterial (p < 0,001).
Conclusões: os altos valores nas taxas de hemoglobina glicosilada aumentaram três vezes a probabilidade de DN. A detecção e o tratamento da neuropatia diabética dolorosa são um desafio, mas a adoção de um protocolo de detecção contribui para a prevenção secundária dessa manifestação.
Downloads
Referências
American Diabetes Association. Standards of Medical Care in Diabetes 2019. Diabetes Care. 2019;42(Suppl. 1):S4–S6. DOI: https://doi.org/10.2337/dc19-Srev01
Iqbal Z, Azmi S, Yadav R, Lim J, Malik RA, Alam U., et al. Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy. Clin Ther. 2018;40(6):828-849. DOI: https://doi.org/10.1016/j.clinthera.2018.04.001
Brazilian Diabetes Society. Diabetic Neuropathies: Position of the American Diabetes Association. 2019. DOI: https://doi.org/10.2337/dc16-2042
Sloan G, Shillo P, Selvarajah D, Wu J, Wilkinson ID, Tracey I, et al. A new look at painful diabetic neuropathy. Diabetes Res Clin Pract. 2018;144:177-191. DOI: https://doi.org/10.1016/j.diabres.2018.08.020
Shillo P, Sloan G, Greig M, Hunt L, Selvarajah D, Elliott J, et al. Painful and painless diabetic neuropathies: what is the difference? Curr Diabetes Rep. 2019;19:32. DOI: https://doi.org/10.1007/s11892-019-1150-5
Oliveira Volpe CM, Villar-Delfino PH, Ferreira dos Anjos PM, Nogueira-Machado JA. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis. 2018:9,119. DOI: https://doi.org/10.1038/s41419-017-0135-z
Raputova J, Srotova I, Vlckova E, Sommer C, Uceyler N, Birklein F, et al. Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. Pain. 2017;158:2340–53. DOI: https://doi.org/10.1097/j.pain.0000000000001034
Brazilian Diabetes Society. Guidelines for the Brazilian Society of Diabetes: 2013-2014. São Paulo: Pharmaceutical Ac, 2014. Available from: https://nutritotal.com.br/pro/wp-content/uploads/sites/3/2014/04/342-diretrizessbd.pdf
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, et al. Neuropathic pain. Nat Rev Dis Primers. 2017;16(3). DOI: https://doi.org/10.1038/nrdp.2017.2
Raputova J, Vlckova E, Sommer C, Üçeyler N, Birklein F, Rittner HL, et al. Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. Pain. 2017;158(12):2340-2353. DOI: https://doi.org/10.1097/j.pain.0000000000001034
Sifuentes-Franco S, Padilla-Tejeda DE, Carrillo-Ibarra S, Miranda-Díaz AG. Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy. Int J Endocrinol. 2018;1. DOI: https://doi.org/10.1155/2018/1875870
Zhou W, Yuan Yao Y, Li J, Wu D, Zhao M, Yan Z, et al. TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway. Front Mol Neurosci. 2019;12:193. DOI: https://doi.org/10.3389/fnmol.2019.00193
Oliveira FB, Botelho KKP, Bezerra AR, Azevedo DIO, Couto CCS, Martins EF. Cross-cultural adaptation to Brazilian Portuguese of the Michigan neuropathy screening Instrument: MNSI - Brazil. Clinical Sales, Criteria and Tools. Arq Neuropsiquiatr. 2016;74(8):653-6612. DOI: https://doi.org/10.1590/0004-282X20160094
Barbosa M, Saavedra A, Severo M, Maier C, Carvalho D. Validation and reliability of the Portuguese version of the Michigan Neuropathy Screening Instrument. Pain Pract. 2016;17(4):514-521. DOI: https://doi.org/10.1111/papr.12479
Schestatsky C, Félix-Torres V, Chaves MLF, Câmara-Ehlers B, Mucenic T, Caumo W, et al. Brazilian Portuguese validation of the Leeds assessment of neuropathic symptoms and signs for patients with chronic pain. Pain Medicine, 2011;12:1544–1550. DOI: https://doi.org/10.1111/j.1526-4637.2011.01221.x
Santos JG, Brito JO, De Andrade DC, Kaziyama VM, Ferreira KA, Souza I, et al. Translation to Portuguese and validation of the Douleur Neuropathique 4 questionnaire. J Pain. 2011;11(5):484-90. DOI: https://doi.org/10.1016/j.jpain.2009.09.014
Ferreira KA, Teixeira MJ, Mendonza TR, Cleeland CS. Validation of brief pain inventory to Brazilian patients with pain. Support Care Cancer. 2011;19(4):505-11. DOI: https://doi.org/10.1007/s00520-010-0844-7
Sarah A, Endrizzi MD, James P, Rathmell MD, Robert W, Hurley MD. Painful Peripheral Neuropathies. Essentials of Pain Medicine. 4ed. 2018: 273-282. DOI: https://doi.org/10.1016/B978-0-323-40196-8.00032-2
MNSI - Michigan Neuropathy Screening Instrument. Michigan Diabetes Research and Training Center. 2010. Available from: http://www.med.umich.edu/borc/profs/documents/svi/MNSI_patient.pdf
Sartor CD, Oliveira MD, Campos V, Ferreira JSSP, Sacco ICN. Cross-cultural adaptation and measurement properties of the Brazilian Version of the Michigan Neuropathy Screening Instrument. Braz J Phys Ther. 2018;22(3):222-230. DOI: https://doi.org/10.1016/j.bjpt.2017.10.004
Crucru G, Truini A. Neuropathic Pain: The Scope of the Problem. Pain and Therapy. 2017;6:1–3. DOI: https://doi.org/10.1007/s40122-017-0086-1
Carvalho AB, Garcia JS, Silva TKM, Riberio JVF. Translation and transcultural adaptation of pain quality assessment scale (PQAS) to Brazilian version. Braz J Anestesiol. 2016;66(1):94-104. DOI: https://doi.org/10.1016/j.bjane.2013.10.018
Agoons BB, Tchapmi D, Boli AO, Katte JC. Clinical utility of the DN4 questionnaire in the assessment of neuropathic pain in patients with type 2 diabetes: experience from a newly created diabetes clinic in Cameroon. PAMJ - Clinical Medicine. 2020:165(3). DOI: https://doi.org/10.11604/pamj-cm.2020.3.165.23789
Ministry of Health, Health Care Secretariat, Ordinance No. 1,083, of October 2, 2012. Available from: http://bvsms.saude.gov.br/bvs/saudelegis/sas/2012/prt1083_02_10_2012.html
Moreno RA, Moreno DH. Escalas de depressão de Montgomery & Asberg (MADRS) e de Hamilton (HAM-D). Rev Psiquiatr Clin. 1998;25:262-72. https://pesquisa.bvsalud.org/portal/resource/pt/lil-228053
Katigari MR, Ayatollahi H, Malek M, Haghighi MK. Fuzzy expert system for diagnosing diabetic neuropathy. World J Diabetes. 2017;8(2):80-88. DOI: https://doi.org/10.4239/wjd.v8.i2.80
Rouquayrol MZ, Gurge M. Epidemiologia e Saúde. 8 ed. Rio de Janeiro. Meedbook, 2017.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(41). DOI: https://doi.org/10.1038/s41572-019-0092-1
Assunção A, Campos D, Marques R, Cunha I, Santos P, Martins A, et al. The impact of demographic and clinical characteristics on diabetic painful neuropathy. Rom J Intern Med. 2020;58(1):13–19. DOI: https://doi.org/10.2478/rjim-2019-0019
Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019 Aug 27;19(10):86. DOI: https://doi.org/10.1007/s11892-019-1212-8
Cortez J, Reis C, Cardoso Y, Onofre A, Piovezan AP. Prevalência de dor neuropática e fatores associados em portadores de diabetes mellitus tipo 2 atendidos em ambulatório médico* SC. Rev Dor. 2014;15(4). DOI: https://doi.org/10.5935/1806-0013.20140055
Gylfadottir SS, Christensen DH, Nicolaisen SK, Andersen H, Callaghan BC, Itani M, Khan KS, et al. Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. Pain. 2019. DOI: https://doi.org/10.1097/j.pain.0000000000001744
Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, et al. Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain. 2017;158(2):261-272. DOI: https://doi.org/10.1097/j.pain.0000000000000753
Celik S, Yenidunya G, Temel E, Purisa S, Uzum AK, Gul N, et al. Utility of DN4 questionnaire in assessment of neuropathic pain and its clinical correlations in Turkish patients with diabetes mellitus. Kidney Care Diabetes. 2016;10(4): 259-64. DOI: https://doi.org/10.1016/j.pcd.2015.11.005
Jensen TS, Finnerup NB. Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. Lancet Neurol. 2014;13(9):924-35. DOI: https://doi.org/10.1016/S1474-4422(14)70102-4
Garoushi S, Jonhson MI, Tashani OA. A cross-sectional study to estimate the point prevalence of painful diabetic neuropathy in Eastern Libya. BMC Public Health. 2019;19:78. DOI: https://doi.org/10.1186/s12889-018-6374-9
American Diabetes Association. Standards of Medical Care in Diabetes — 2017. Diabetes Care. 2017;40(1):S1–S135. https://care.diabetesjournals.org/content/diacare/suppl/2016/12/15/40.Supplement_1.DC1/DC_40_S1_final.pdf
Rolim LC, Koga da Silva EM, De Sá JR, Dib SA. A Systematic Review of Treatment of Painful Diabetic Neuropathy by Pain Phenotype versus Treatment Based on Medical Comorbidities. Front Neurol. 2017. DOI: https://doi.org/10.3389/fneur.2017.00285
Pop-Busui R, Boulton AJM, Feldman EL, Bril V, Freeman R, Malik RA, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136-54. DOI: https://doi.org/10.2337/dc16-2042
Pai YW, Lin CH, Lee IT, Chang MH. Prevalence and biochemical risk factors of diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese adults with type 2 diabetes mellitus. Diabetes Metab Syndr. 2018;12(2):111-116. DOI: https://doi.org/10.1016/j.dsx.2017.09.013
Ponirakis G, Elhadd T, Chinnaiyan S, Dabbous Z, Siddiqui M, Al-Muhannadi H, et al. Prevalence and management of diabetic neuropathy in secondary care in Qatar. Diabetes Metab Res Rev. 2020;8. DOI: https://doi.org/10.1002/dmrr.3286
Pedrosa HC, Vilar L, Boulton AJM et al. Neuropatias e pés Diabéticos. ACF. 2013.
Udall M, Kudel I, Cappelleri JC, Sadosky A, King-Concialdi K, Parsons B, et al. Epidemiology of physician-diagnosed neuropathic pain in Brazil. J Pain Res. 2019;7(12):243-253. DOI: https://doi.org/10.2147/JPR.S160504
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2021 Aquichan
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
1. Proposta de Política para Periódicos de Acesso Livre
Autores que publicam nesta revista concordam com os seguintes termos:
- Esta revista e os seus artigos estão publicados com a licença Creative Commons Atribuição-NãoComercial-SemDerivações 4.0 Internacional (CC BY-NC-ND 4.0). Você tem o direito de compartilhar, copiar e redistribuir o material em qualquer suporte ou formato. Para que isto ocorra: você deve dar o crédito apropriado, prover um link para a licença e indicar se mudanças foram feitas; você não pode usar o material para fins comerciais; e, se você remixar, transformar ou criar a partir do material, você não pode distribuir o material modificado.